Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
基本信息
- 批准号:7050616
- 负责人:
- 金额:$ 15.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-04-07 至 2010-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Age-related bone fracture is only partially explained by the reduction in bone mass that universally occurs with aging. The failure to predict fracture comes in part from a) the loss of geometrical information when projection x-ray methods are used to measure bone mass, b) ignorance of sufficiently detailed information about the failure properties of bone, and also c) ignorance of detailed in vivo loads on bones (Fracture risk is related to the ratio of load to strength, rather than to bone strength alone). A fourth barrier to accurately predicting fracture risk is that changes in bone tissue mechanical properties caused by age or disease related changes in the collagen, non-collagenous proteins or water content of bone are not detectable to xray methods. As a result of the invisibility of soft tissue changes to x-ray detection, there are age and menopause related changes in tissue material properties (in bone quality) that are invisible, not understood and that unpredictably increase bone fracture risk.
Our data support the novel working hypotheses: 1) The viscoelastic properties of bone affect the fracture toughness and apparent strength of bone tissue, 2) The viscoelastic properties of ovine bone degrade after ovariectomy, causing a decrease in the strength and fracture toughness of bone tissue for rates of loading associated with falls.
The main goal of the proposed work is to determine the onset time of viscoelastic property degradation and whether cortical bone can recover normal viscoelastic and strength properties with estrogen replacement.
描述(由申请方提供):骨质疏松相关骨折仅部分可通过随年龄增长而普遍发生的骨量减少来解释。预测骨折的失败部分来自a)当使用投影X射线方法测量骨量时几何信息的丢失,B)忽略关于骨的失效特性的足够详细的信息,以及c)忽略骨上的详细体内载荷(骨折风险与载荷与强度的比率有关,而不是单独与骨强度有关)。准确预测骨折风险的第四个障碍是由年龄或疾病相关的骨胶原、非胶原蛋白或水含量的变化引起的骨组织机械性能的变化不能用X射线方法检测。由于软组织变化对X射线检测的不可见性,组织材料性质(骨质)中存在年龄和绝经相关的变化,这些变化是不可见的、不被理解的,并且不可预测地增加骨折风险。
我们的数据支持新的工作假设:1)骨的粘弹特性影响骨组织的断裂韧性和表观强度,2)卵巢切除术后羊骨的粘弹特性下降,导致骨组织的强度和断裂韧性下降,因为负载率与福尔斯有关。
拟议工作的主要目标是确定粘弹性能退化的开始时间以及皮质骨是否可以通过雌激素替代恢复正常的粘弹和强度性能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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CLIFFORD MICHAEL LES其他文献
CLIFFORD MICHAEL LES的其他文献
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{{ truncateString('CLIFFORD MICHAEL LES', 18)}}的其他基金
Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
- 批准号:
7387437 - 财政年份:2005
- 资助金额:
$ 15.7万 - 项目类别:
Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
- 批准号:
6924988 - 财政年份:2005
- 资助金额:
$ 15.7万 - 项目类别:
Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
- 批准号:
7197332 - 财政年份:2005
- 资助金额:
$ 15.7万 - 项目类别:
Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
- 批准号:
7600520 - 财政年份:2005
- 资助金额:
$ 15.7万 - 项目类别:
MODULATION OF LOCAL BONE TISSUE MATERIAL PROPERTIES
局部骨组织材料特性的调节
- 批准号:
6512163 - 财政年份:2001
- 资助金额:
$ 15.7万 - 项目类别:
MODULATION OF LOCAL BONE TISSUE MATERIAL PROPERTIES
局部骨组织材料特性的调节
- 批准号:
6632753 - 财政年份:2001
- 资助金额:
$ 15.7万 - 项目类别:
MODULATION OF LOCAL BONE TISSUE MATERIAL PROPERTIES
局部骨组织材料特性的调节
- 批准号:
6769328 - 财政年份:2001
- 资助金额:
$ 15.7万 - 项目类别:
MODULATION OF LOCAL BONE TISSUE MATERIAL PROPERTIES
局部骨组织材料特性的调节
- 批准号:
6383216 - 财政年份:2001
- 资助金额:
$ 15.7万 - 项目类别:
MATERIAL PROPERTIES AND REMODELING IN THE METACARPUS
掌骨的材料特性和重塑
- 批准号:
2077977 - 财政年份:1994
- 资助金额:
$ 15.7万 - 项目类别:
MATERIAL PROPERTIES AND REMODELING IN THE METACARPUS
掌骨的材料特性和重塑
- 批准号:
2077976 - 财政年份:1993
- 资助金额:
$ 15.7万 - 项目类别:
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