Understanding the Impact of Environmental Structure and Sub-inhibitory Antibiotic Concentrations on the Emergence of Resistance

了解环境结构和亚抑制抗生素浓度对耐药性出现的影响

• 批准号: 2241114
• 金额: --
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2241114
• 关键词: Understanding; Impact; Environmental; Structure; Sub

This studentship will develop novel understanding on the physical principle underlying antibiotic accumulation and efficacy against gram-negative bacteria. These bacteria constitute nowadays a serious threat to human and animal health due to the spread of antibiotic resistance. By developing a holistic approach encompassing biophysics, mathematics and microbiology, the student wiill be able to determine the pathways for molecular influx and efflux across the gram-negative double membrane. These pathways are likely to depend on the antibiotic employed during treatment of bacterial infection. Therefore, the student will investigate the transport of a panel of commonly employed antibiotics. The novel knowledge that will be developed in this project will inform the pharmaceutical company on the development of new drugs and on the repurposing of existing drugs by determine the pathways for the accumulation of these molecules in gram-negative bacteria. As such this research will have a beneficial impact on both our society and economy by, in the long term, permitting to lower down the cost of the antibiotic discovery pipeline

该研究将对抗生素积累的物理原理和对革兰氏阴性菌的有效性产生新的认识。由于抗生素耐药性的传播，这些细菌如今对人类和动物健康构成严重威胁。通过开发一个整体的方法，包括生物物理学，数学和微生物学，学生将能够确定分子流入和流出的途径，通过革兰氏阴性双膜。这些途径可能取决于细菌感染治疗期间使用的抗生素。因此，学生将研究一组常用抗生素的运输。该项目将开发的新知识将通过确定这些分子在革兰氏阴性菌中积累的途径，为制药公司提供新药开发和现有药物再利用的信息。因此，从长远来看，这项研究将对我们的社会和经济产生有益的影响，从而降低抗生素发现管道的成本。