Potentiation and repurposing of macrolide antimicrobials against Gram-negative pathogens for clinical applications in human and veterinary medicine

改进的抗菌策略的发展是一项重要的全球挑战。该项目旨在加强非关键大环内酯类抗生素的活性，使其可用于取代人类和兽医临床使用的关键抗生素，如粘菌素。这一目标将通过将大环内酯类抗生素与多肽模拟物(肽模拟物)和抗菌聚合物复合和结合来实现，这一点建立在我们实验室强有力的体外证据的基础上。抗菌、免疫调节和微生物组作用将在体外和体内进行测试，并使用细胞系统和猪和/或禽类模型进行测试。

The development of improved antibacterial strategies is an important global challenge. This project aims to potentiate the activity of non-critical macrolide antibiotics to the degree that they can be used to replace the use of critical antibiotics in clinical use in human and veterinary medicine, e.g., colistin. This aim will be achieved by complexing and conjugating macrolide antibiotics with peptide mimics (peptidomimetics) and antimicrobial polymers, building on strong in vitro evidence in our laboratories. The antibacterial, immunomodulatory and microbiome effects will be tested in vitro and in vivo, and by using cell systems and porcine and/or avian models.