Assessing Microstructure of Carotid Disease with MRI/MRS

用 MRI/MRS 评估颈动脉疾病的微观结构

• 批准号: 6623332
• 负责人: RONALD L WOLF
• 金额: $ 17.26万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6623332
• 关键词: artery stenosis; atherosclerosis; atherosclerotic plaque; bioimaging /biomedical imaging; calcium; cardiovascular disorder risk; carotid artery; clinical research; computed axial tomography; endarterectomy; human subject; magnetic resonance imaging; normal ossification; nuclear magnetic resonance spectroscopy; prognosis; sign /symptom; stroke; vasoconstriction

DESCRIPTION (provided by the applicant): The applicant is a neuroradiologist interested in application of MR and CT methodologies to the study of stroke, with the immediate goal of obtaining a broadened understanding of carotid atherosclerosis and its relationship to stroke. One major emphasis of this application is toward the development of a detailed understanding of structural MR and CT techniques for imaging the arterial wall and atherosclerotic plaque. Another major emphasis will be placed on gaining a mastery of biostatistics to improve study design and data collection and interpretation. The long-term goal is to acquire tools to become an independent investigator in the study of stroke. Stroke is the third leading cause of mortality and the leading cause of disability in the United States, and a significant fraction of all ischemic strokes are caused by carotid atherosclerotic disease. Often stroke is preceded by neurologic symptoms and may be preventable with timely intervention. The degree of arterial stenosis is a major risk factor, but there is evidence that factors unrelated to the size of the vascular constriction play a role in causing symptoms. These include the morphology and composition of the atherosclerotic plaque itself. The following specific aims will be pursued to evaluate the hypothesis that the plaque composition is an independent predictor of symptoms: 1) A pilot study will be initiated wherein symptomatic and asymptomatic patients (N = 50 each) with clinically significant carotid stenosis (>70%) who will subsequently undergo carotid endarterectomy (CEA) will be recruited. These patients will undergo high-resolution MR imaging of the carotid artery at 1.5 Tesla. 2) After CEA, microimaging of the intact plaque specimen will be performed at 9.4 Tesla and compared with in vivo imaging. Micro-CT imaging will also be performed. 13-C NMR spectroscopy of the intact specimen will be performed at 9.4 Tesla, and the acquisitions will be repeated after plaque extraction. Plaque lipid profile and calcium content will be studied as a means to characterize the lesion and evaluate the association between plaque characteristics and patients' symptomatology.

描述（由申请人提供）：申请人是一名神经放射科医生 对MR和CT方法在卒中研究中的应用感兴趣， 其直接目标是获得对颈动脉的更广泛的理解， 动脉粥样硬化及其与中风的关系。其中一个主要重点是 应用程序是为了发展对结构的详细了解， MR和CT技术用于动脉壁和动脉粥样硬化斑块的成像。 另一个主要重点将放在掌握生物统计学， 改进研究设计、数据收集和解释。远景目标 是获得工具，成为一个独立的研究者， 中风 中风是死亡的第三大原因，也是死亡的主要原因。 在美国的残疾中， 中风是由颈动脉粥样硬化疾病引起的。中风通常发生在 神经系统症状，可以通过及时干预来预防。的 动脉狭窄程度是一个主要的危险因素，但有证据表明， 与血管收缩的大小无关的因素在 引起症状。这些包括的形态和组成的 动脉粥样硬化斑块本身。 将追求以下具体目标，以评估以下假设： 斑块组成是症状的独立预测因子：1）初步研究 将启动，其中有症状和无症状患者（各N = 50） 具有临床意义的颈动脉狭窄（>70%），随后 将招募接受颈动脉内膜切除术（CEA）的患者。这些患者将 在1.5特斯拉下对颈动脉进行高分辨率MR成像。2)后 CEA，将在9.4特斯拉下对完整斑块样本进行显微成像 并与体内成像进行比较。还将进行Micro-CT成像。 将在9.4特斯拉下对完整样本进行13-C NMR光谱分析， 并且在斑块提取之后重复采集。斑块脂质 将研究剖面和钙含量，作为表征 病变，并评估斑块特征与 病人的精神病学。