EVALUATION OF VASCULAR MALFORMATION HEMODYNAMICS USING ASL PERFUSION MRI

使用 ASL 灌注 MRI 评估血管畸形血流动力学

• 批准号: 8361984
• 负责人: RONALD L WOLF
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361984
• 关键词: Blood Vessels; Brain; Core-Binding Factor; Development; Evaluation; Excision; Funding; Goals; Grant; Magnetic Resonance; Magnetic Resonance Imaging; Methods; National Center for Research Resources; Operative Surgical Procedures; Patients; Perfusion; Pilot Projects; Principal Investigator; Research; Research Infrastructure; Resources; Shunt Device; Source; Techniques; Testing; Therapeutic Embolization; United States National Institutes of Health; cost; hemodynamics; malformation; novel; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this R21 project is to test the hypothesis that ASL can be used as a novel method to detect and quantify AV shunting in AVM or AVF, while simultaneously evaluating effects on brain perfusion. The first part of the proposal focuses on further development and optimization of the ASL perfusion MRI technique for use in this setting. In the second part of the proposal, patients with suspected AVM or AVF who are undergoing DSA will also be studied using the optimized ASL perfusion MRI technique in a pilot study to assess its accuracy. In the third part of the proposal, the information obtained in the pilot study will be further analyzed to determine whether AV shunting can be quantified, whether alterations in CBF related to an AVM or AVF can be detected, and whether changes in AV shunt or CBF can be detected in those patients undergoing surgical excision or embolization.

这个子项目是利用这些资源的众多研究子项目之一