EVALUATION OF VASCULAR MALFORMATION HEMODYNAMICS USING ASL PERFUSION MRI

使用 ASL 灌注 MRI 评估血管畸形血流动力学

• 批准号: 8169075
• 负责人: RONALD L WOLF
• 金额: $ 0.87万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169075
• 关键词: Blood Vessels; Brain; Computer Retrieval of Information on Scientific Projects Database; Core-Binding Factor; Development; Evaluation; Excision; Funding; Goals; Grant; Institution; Magnetic Resonance Imaging; Methods; Operative Surgical Procedures; Patients; Perfusion; Pilot Projects; Research; Research Personnel; Resources; Shunt Device; Source; Techniques; Testing; Therapeutic Embolization; United States National Institutes of Health; hemodynamics; malformation; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this R21 project is to test the hypothesis that ASL can be used as a novel method to detect and quantify AV shunting in AVM or AVF, while simultaneously evaluating effects on brain perfusion. The first part of the proposal focuses on further development and optimization of the ASL perfusion MRI technique for use in this setting. In the second part of the proposal, patients with suspected AVM or AVF who are undergoing DSA will also be studied using the optimized ASL perfusion MRI technique in a pilot study to assess its accuracy. In the third part of the proposal, the information obtained in the pilot study will be further analyzed to determine whether AV shunting can be quantified, whether alterations in CBF related to an AVM or AVF can be detected, and whether changes in AV shunt or CBF can be detected in those patients undergoing surgical excision or embolization.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个R21项目的目标是检验ASL可以作为一种新的方法用于 检测和量化AVM或AVF的房室分流，同时评估对大脑的影响 灌流。建议的第一部分侧重于进一步发展和优化 在这种情况下使用的ASL灌注MRI技术。在提案的第二部分，患者 正在接受DSA的疑似AVM或AVF患者也将使用优化的ASL进行研究 磁共振灌注成像技术在一项初步研究中评估其准确性。在提案的第三部分， 在试点研究中获得的信息将被进一步分析，以确定AV是否 分流可以被量化，无论是否可以检测到与AVM或AVF相关的CBF的改变， 手术患者是否可以检测到房室分流或脑血流量的变化 切除或栓塞。