EVALUATION OF VASCULAR MALFORMATION HEMODYNAMICS USING ASL PERFUSION MRI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 该R21项目的目标是测试ASL可用作一种新方法的假设， 检测和量化AVM或AVF中的AV分流，同时评估对大脑的影响 灌注。提案的第一部分重点关注进一步开发和优化 ASL灌注MRI技术用于这种情况。在第二部分，患者 还将使用优化的ASL研究正在接受DSA的疑似AVM或AVF患者 灌注MRI技术在试点研究，以评估其准确性。在提案的第三部分， 将进一步分析试点研究中获得的信息，以确定是否存在AV 分流可以量化，是否可以检测到与AVM或AVF相关的CBF改变， 以及在接受手术的患者中是否可以检测到AV分流或CBF的变化 切除或栓塞。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this R21 project is to test the hypothesis that ASL can be used as a novel method to detect and quantify AV shunting in AVM or AVF, while simultaneously evaluating effects on brain perfusion. The first part of the proposal focuses on further development and optimization of the ASL perfusion MRI technique for use in this setting. In the second part of the proposal, patients with suspected AVM or AVF who are undergoing DSA will also be studied using the optimized ASL perfusion MRI technique in a pilot study to assess its accuracy. In the third part of the proposal, the information obtained in the pilot study will be further analyzed to determine whether AV shunting can be quantified, whether alterations in CBF related to an AVM or AVF can be detected, and whether changes in AV shunt or CBF can be detected in those patients undergoing surgical excision or embolization.