African-American Women's Response to Physical Activity

描述：（由申请人提供）本3年计划书的近期目标 是为了加强候选人的研究知识和技能，并提供一个 有机会在身体活动的调查中综合这些， 与心血管疾病控制和预防相关的其他结局 妇女，特别是少数民族妇女。总体目标是生产 一个独立的调查员，其职业承诺是生产和 传播将对少数群体健康产生影响的科学 妇女为了实现这一目标，候选人将追求一个3阶段的计划， 在一个研究要点模型，由受训者和她的审查， 共同导师制定了9项培训目标。这些目标规定， 从知识获取到技能发展再到综合。 拉什大学是一个有利于多学科生物医学和 临床研究项目。两名具有以患者为导向的专业知识的导师 结果和心血管研究（来自护理学院和 医学）将监督候选人的培训和执行 研究项目。此外，3名高级研究员和内容专家，在 妇女和少数民族人口的征聘和留用领域， 以病人为导向的结果，将作为顾问教师。 本研究采用随机对照设计， 研究短时间的累积体力活动对血液的影响 压力[BP]和健康相关的生活质量在非洲裔美国妇女， 高血压高危人群。这项研究不仅将量化影响 运动处方对血压和生活质量的影响，而且， 时间，研究内皮功能和血流动力学相关性的作用 血压的变化。鉴于有充分证据表明 非裔美国妇女肥胖的患病率，低水平的身体 活动和健身在这些相同的妇女，和身体之间的联系， 活动/健身和肥胖伴血压升高，高血压倾向和轻度 高血压非裔美国妇女是体力活动的合理目标 干预本项目的发现以及知识和技能 作为培训经验的一部分，将使候选人能够 提出一个ROI级别的调查，[作为主要研究者，在 多学科的以病人为中心的研究。

DESCRIPTION: (provided by applicant) The immediate goal of this 3-year proposal is to strengthen the candidate's research knowledge and skills and provide an opportunity to synthesize these in the investigations of physical activity and other outcomes as they relate to cardiovascular disease control and prevention in women, especially those of ethnic minorities. The overall goal is to produce an independent investigator whose career commitment is to the production and dissemination of science that will make an impact on the health of minority women. To reach this goal, the candidate will pursue a 3-phase program, based on a Research Essentials model, the review of which by the trainee and her co-mentors produced 9 training objectives. These objectives provide for progression from knowledge acquisition to skill development to synthesis. Rush University is an environment conducive to multidisciplinary biomedical and clinical research projects. Two mentors with expertise in patient-oriented outcomes and cardiovascular research (from the colleges of nursing and medicine, respectively) will oversee the candidate's training and execution of the research project. In addition, 3 senior researchers and content experts, in the areas of recruitment and retention in women and minority populations and patient-oriented outcomes, will serve as consultant faculty. This propose research synthesis study uses a randomized, controlled design to investigate the impact of short bouts of accumulated physical activity on blood pressure [BP] and health-related quality of life in African-American women, a high-risk group for hypertension. This study will not only quantify the impact of exercise prescription on BP and quality of life, but also, for the first time, investigate the role of endothelial function and hemodynamic correlates of BP change in this high-risk population. Given the well documented high prevalence of obesity in African-American women, the low levels of physical activity and fitness in these same women, and the link between physical activity/fitness and obesity with elevated BP, hypertension-prone and mildly hypertensive African-American women are logical targets for a physical activity intervention. Findings from this project as well as the knowledge and skills developed as part of the training experience, will enable the candidate to propose an ROI level investigation, [as the principal investigator, in multidisciplinary patient-oriented research.]