Diamond and Hydrogenated Carbon Microelectrodes

金刚石和氢化碳微电极

基本信息

  • 批准号:
    6506983
  • 负责人:
  • 金额:
    $ 13.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-08-01 至 2005-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The proposed research will fabricate, evaluate and develop diamond and hydrogenated carbon fiber microelectrodes for use in the measurement and detection of electroactive neurotransmitters, related metabolites and other bioanalytes. These new, low oxide and chemically stable microelectrodes have the potential to significantly impact in vitro and in vivo neuroelectrochemical measurements because they solve several problems/complications often encountered with common sp2 carbon fiber microelectrodes. These problems/complications exist because of the presence of electroactive and ionizable surface carbon-oxygen functionalities. Boron-doped microcrystalline and nitrogen-incorporated nanocrystalline diamond films conformally deposited on 20-100 micron diameter W and Mo fibers, and hydrogen plasma treated carbon fibers (pitch and pan-based, 10-40 micron diameter) will be the microelectrodes investigated. These electrode materials offer advantages compared to commonly used sp2 carbon electrodes including a lower voltammetric and amperometric background current; no background voltammetnc features associated with electroactive surface carbon-oxygen functionalities; no variations in the response sensitivity for charged solution analytes due to the absence of ionizable carbon-oxygen functionalities; resistance to fouling due to the nonpolar, hydrogen-terminated surface; low limits of detection; and improved response precision and stability.The goals of the research are (i) to prepare and comprehensively characterize the microelectrodes, (ii) to demonstrate their efficacy for the measurement of neurotransmitters, metabolites and bioanalytes, (iii) to verify that the low oxide surfaces solve the problems/complications that exist in fast scan voltammetric measurements when oxygen functionalized electrodes are used, (iv) to develop a detailed understanding of the electrode reaction kinetics and mechanisms at the hydrogen-terminated surfaces and (v) to apply the electrodes in FIA-EC, LC-EC and CE-EC assays with the objective of significantly improving the analytical detection figures of merit.
描述(由申请人提供):拟议的研究将制造,评估和开发金刚石和氢化碳纤维微电极,用于测量和检测电活性神经递质,相关代谢物和其他生物分析物。这些新的、低氧化物和化学稳定的微电极有可能显著影响体外和体内神经电化学测量,因为它们解决了常见sp2碳纤维微电极经常遇到的几个问题/并发症。这些问题/并发症的存在是因为存在电活性和可电离的表面碳-氧官能团。硼掺杂的微晶和氮结合的纳米晶金刚石薄膜共形沉积在20-100微米直径的W和Mo纤维,和氢等离子体处理的碳纤维(沥青和PAN基,10-40微米直径)将微电极的研究。与常用的sp2碳电极相比,这些电极材料提供了优点,包括较低的伏安和安培背景电流;没有与电活性表面碳-氧官能团相关的背景伏安特征;由于不存在可电离的碳-氧官能团,对带电溶液分析物的响应灵敏度没有变化;由于非极性、氢封端的表面而抗结垢;低检测限;该研究的目标是(i)制备和全面表征微电极,(ii)证明其用于测量神经递质、代谢物和生物分析物的功效,(iii)验证低氧化物表面解决了问题/当使用氧官能化电极时在快速扫描伏安法测量中存在的复杂性,(iv)详细了解氢封端表面处的电极反应动力学和机制,以及(v)将电极应用于FIA-EC中,LC-EC和CE-EC测定,目的是显著提高分析检测优值。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

GREG M SWAIN其他文献

GREG M SWAIN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('GREG M SWAIN', 18)}}的其他基金

Using Electrochemical Methods to Probe Neuronal Signaling in the GI Tract
使用电化学方法探测胃肠道中的神经元信号传导
  • 批准号:
    7895874
  • 财政年份:
    2009
  • 资助金额:
    $ 13.68万
  • 项目类别:
Using Electrochemical Methods to Probe Neuronal Signaling in the GI Tract
使用电化学方法探测胃肠道中的神经元信号传导
  • 批准号:
    7739900
  • 财政年份:
    2009
  • 资助金额:
    $ 13.68万
  • 项目类别:
Sympathetic Neural Control Mechanisms in Hypertension
高血压的交感神经控制机制
  • 批准号:
    7112291
  • 财政年份:
    2002
  • 资助金额:
    $ 13.68万
  • 项目类别:
Diamond and Hydrogenated Carbon Microelectrodes
金刚石和氢化碳微电极
  • 批准号:
    6784020
  • 财政年份:
    2002
  • 资助金额:
    $ 13.68万
  • 项目类别:
Diamond and Hydrogenated Carbon Microelectrodes
金刚石和氢化碳微电极
  • 批准号:
    6631452
  • 财政年份:
    2002
  • 资助金额:
    $ 13.68万
  • 项目类别:
Sympathetic Neural Control Mechanisms in Hypertension
高血压的交感神经控制机制
  • 批准号:
    6967340
  • 财政年份:
    2002
  • 资助金额:
    $ 13.68万
  • 项目类别:
Sympathetic Neural Control Mechanisms in Hypertension
高血压的交感神经控制机制
  • 批准号:
    7263185
  • 财政年份:
    2002
  • 资助金额:
    $ 13.68万
  • 项目类别:

相似海外基金

New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2022
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Discovery Grants Program - Individual
New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2021
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Discovery Grants Program - Individual
New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2020
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Discovery Grants Program - Individual
New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2019
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Discovery Grants Program - Individual
New directions for x-ray spectrometry from portable to synchrotron science
X 射线光谱测定从便携式到同步加速器科学的新方向
  • 批准号:
    RGPIN-2018-03902
  • 财政年份:
    2018
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Discovery Grants Program - Individual
Advances in x-ray spectrometry: new science through new sources
X 射线光谱测定的进展:新来源的新科学
  • 批准号:
    261523-2013
  • 财政年份:
    2017
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Discovery Grants Program - Individual
Advances in x-ray spectrometry: new science through new sources
X 射线光谱测定的进展:新来源的新科学
  • 批准号:
    261523-2013
  • 财政年份:
    2016
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Discovery Grants Program - Individual
Advances in x-ray spectrometry: new science through new sources
X 射线光谱测定的进展:新来源的新科学
  • 批准号:
    261523-2013
  • 财政年份:
    2015
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Discovery Grants Program - Individual
Application of energy dispersive X-ray spectrometry (EDX) in forensic practice
能量色散 X 射线光谱 (EDX) 在法医学实践中的应用
  • 批准号:
    15K19273
  • 财政年份:
    2015
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Advances in x-ray spectrometry: new science through new sources
X 射线光谱测定的进展:新来源的新科学
  • 批准号:
    261523-2013
  • 财政年份:
    2014
  • 资助金额:
    $ 13.68万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了