POSTDOCTORAL RESEARCH TRAINING IN CANCER IMMUNOLOGY

描述(由申请人提供)：过去几年是达纳-法伯癌症研究所(DFCI)和哈佛医学院社区取得非凡科学成就和癌症研究扩张的时期。虽然在癌症的诊断和治疗方面取得了重大进展，但这种疾病仍然是儿童和成人死亡的主要原因。我们对免疫反应的基本了解取得了重要进展，为白血病和实体瘤的诊断和治疗提供了新的临床方法。在肿瘤抑制基因、细胞周期调控、癌基因信号转导、细胞分化、细胞凋亡调控、器官发生和血管生成等基础生命科学领域取得了重大进展。靶向癌症治疗的最新进展，癌细胞成像的新模式，以及对遗传学和癌症风险的更深入了解，突显了这些发现对转化研究的潜力，这反过来又为当今的年轻科学家开辟了新的机会领域。这一努力的一个重要部分是培训年轻的基础和临床免疫学科学家，使其成为癌症免疫学的独立研究人员。在DFCI，翻译研究多年来一直是基础免疫学和临床免疫学教师之间持续合作的努力。Dana-Farber/哈佛癌症中心是附属医院的联盟，最近成立的Dana-Farber/哈佛癌症中心使我们的培训人员得以扩大，包括来自整个哈佛医学院社区的杰出科学家，他们都是基础和转化/临床免疫学方面的领先研究人员。此外，扩大的基础设施和核心资源加强了试剂的获取，并为开展研究提供了更有效的框架。该计划将继续由Harvey Cantor博士指导，他与培训计划小组委员会一起负责候选人选择、计划课程、对受训者研究的年度审查以及促进计划内学生和教职员工之间的互动。该计划的长期目标是培养基础科学家在癌症免疫学方面进行独立的高质量研究。

DESCRIPTION (provided by applicant): The last several years have been a period of extraordinary scientific achievement and cancer research expansion, both at Dana-Farber Cancer Institute (DFCI) and within the Harvard Medical School community. Although significant progress has been made in the diagnosis and treatment of cancer, this disease continues to represent a major cause of childhood and adult mortality. Important advances in our fundamental understanding of the immune response have suggested new clinical approaches to the diagnosis and treatment of leukemias and solid tumors. Significant advances have occurred in the areas of basic biological science, including tumor suppressor genes, cell cycle regulation, oncogene signaling, cell differentiation, apoptosis control, organogenesis and angiogenesis. Recent advances in targeted cancer therapies, new modalities of cancer cell imaging, and a deeper understanding of genetics and cancer risk highlight the potential of these discoveries to translational research which, in turn, has opened new areas of opportunity for today's young scientists. An essential part of this effort is the training of young scientists in basic and clinical immunology to become independent investigators in cancer immunology. At DFCI, translational research has been an ongoing collaborative effort between faculty in basic and clinical Immunology for many years. Recent formation of the Dana-Farber/Harvard Cancer Center, a consortium of the affiliated hospitals, has allowed expansion of our training faculty to include distinguished scientists from the entire Harvard Medical School community, all of whom are leading investigators in basic and translational/clinical immunology. In addition, expanded infrastructure and core resources have enhanced access to reagents and provide a more efficient framework in which to carry out research. The program will continue to be directed by Dr. Harvey Cantor who, in conjunction with the Training Program Subcommittee, is responsible for candidate selection, program curriculum, annual review of trainee's research and fostering of interactions among student and faculty members within the Program. The long-range goal of the Program is to train basic scientists to conduct independent high-quality research in cancer immunology.