Body Weight Regulations of Older Adulets
较大成人的体重调节
基本信息
- 批准号:6682140
- 负责人:
- 金额:$ 12.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-09-30 至 2008-08-31
- 项目状态:已结题
- 来源:
- 关键词:age difference basal metabolism bioenergetics body composition body weight clinical research cytokine epidemiology geriatrics human old age (65+) human subject interleukin 1 interleukin 6 leptin patient oriented research polymerase chain reaction radioimmunoassay tumor necrosis factor alpha weight loss
项目摘要
DESCRIPTION (provided by applicant): Dr Michi Yukawa completed her geriatric fellowship at the University of Washington (UW) in June 2000, and she is an Acting Instructor within the Division of Gerontology and Geriatric Medicine (DGGM) at the UW. Prior to her geriatric fellowship, she practiced in Boston MA for five years as an internist. The K-23 Award will give Dr Yukawa time and resources to acquire knowledge and technical skills to become an independent physician scientist. Dr Itamar B Abrass will guide her career development within Geriatric Medicine. Dr D Scott Weigle will be her research mentor and supervise her laboratory work and development of research protocols. Additional faculty members in the DGGM and the Department of Endocrinology of the UW will provide further guidance. She will attend advanced classes in biostatistics at the School of Public Health of the UW. Controlled dietary intervention and physiologic studies will be performed at the Clinical Research Center (CRC) of the University of Washington Medical Center (UWMC). The long-term objective of her research is to determine the underlying pathophysiology of involuntary weight loss and anorexia in the geriatric population. Understanding energy regulation and metabolism in healthy older adults is necessary prior to investigating older adults with involuntary weight loss and anorexia. Previous studies have reported dysregulation of energy intake in older subjects after calorie restriction. Other studies have suggested abnormalities in leptin homeostasis in older adults. Therefore, the specific aims of the proposed project are to test the hypothesis that elevated pro-inflammatory cytokines lead to elevated leptin levels in older adults, which in turn are associated with inability of older adults to recover after a period of moderate caloric restriction. 1) A cross-sectional comparison of healthy community dwelling older and younger adults before and after calorie restriction will be performed. 2) The same cohort of older subjects will be followed for two years to identify factors that predict weight loss in older adults.
[3) The relationship between pro-inflammatory cytokines, leptin levels and involuntary weight loss in older adults will be investigated. Pro-inflammatory cytokines secreted from adipocytes of older adults with and without weight loss and healthy younger subjects will be compared. Leptin levels in culture media will be analyzed by radioimmunoassay, and leptin mRNA in adipocytes will be analyzed by real time RT-PCR. The goal of these studies is to define the relationship of pro-inflamlnatory cytokines and leptin levels to body weight regulation in older adults.]
描述(由申请人提供):Michi Yukawa博士于2000年6月在华盛顿大学(UW)完成了她的老年学研究金,她是UW老年学和老年医学部(DGGM)的代理讲师。在她的老年奖学金之前,她在马萨诸塞州波士顿实习了五年的内科医生。K-23奖将为汤川博士提供时间和资源,以获得知识和技术技能,成为一名独立的医生科学家。Itamar B Abrass博士将指导她在老年医学领域的职业发展。D Scott Weigle博士将成为她的研究导师,并监督她的实验室工作和研究方案的制定。DGGM和UW内分泌学系的其他教员将提供进一步的指导。她将参加华盛顿大学公共卫生学院的生物统计学高级课程。对照饮食干预和生理学研究将在华盛顿大学医学中心(UWMC)的临床研究中心(CRC)进行。她的研究的长期目标是确定老年人群中非自愿体重减轻和厌食症的潜在病理生理学。了解健康老年人的能量调节和代谢是必要的,然后再调查老年人与非自愿减肥和厌食症。先前的研究报告了热量限制后老年受试者的能量摄入失调。其他研究表明,老年人的瘦素稳态异常。因此,拟议项目的具体目的是检验这一假设,即促炎细胞因子升高导致老年人瘦素水平升高,这反过来又与老年人在适度限制热量一段时间后无法恢复有关。1)将对健康社区居住的老年人和年轻人在热量限制前后进行横断面比较。2)同一队列的老年受试者将被随访两年,以确定预测老年人体重减轻的因素。
[3)促炎细胞因子,瘦素水平和老年人的体重不自主下降之间的关系将进行调查。将比较有和没有体重减轻的老年人和健康的年轻受试者的脂肪细胞分泌的促炎细胞因子。将通过放射免疫测定法分析培养基中的瘦素水平,并通过真实的时间RT-PCR分析脂肪细胞中的瘦素mRNA。这些研究的目的是确定促炎细胞因子和瘦素水平与老年人体重调节的关系。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michi Yukawa其他文献
Michi Yukawa的其他文献
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{{ truncateString('Michi Yukawa', 18)}}的其他基金
THE ROLE OF LEPTIN AND CYTOKINES IN BODY WEIGHT REGULATION OF OLDER ADULTS
瘦素和细胞因子在老年人体重调节中的作用
- 批准号:
7603432 - 财政年份:2007
- 资助金额:
$ 12.56万 - 项目类别:
THE ROLE OF LEPTIN AND CYTOKINES IN BODY WEIGHT REGULATION OF OLDER ADULTS
瘦素和细胞因子在老年人体重调节中的作用
- 批准号:
7379315 - 财政年份:2006
- 资助金额:
$ 12.56万 - 项目类别:
THE ROLE OF LEPTIN AND CYTOKINES IN BODY WEIGHT REGULATION OF OLDER ADULTS
瘦素和细胞因子在老年人体重调节中的作用
- 批准号:
7198812 - 财政年份:2005
- 资助金额:
$ 12.56万 - 项目类别:
Role of leptin and cytokines in body weight regulati
瘦素和细胞因子在体重调节中的作用
- 批准号:
6974521 - 财政年份:2004
- 资助金额:
$ 12.56万 - 项目类别:
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