Body Weight Regulations of Older Adulets

较大成人的体重调节

• 批准号: 7265224
• 负责人: Michi Yukawa
• 金额: $ 12.56万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7265224
• 关键词: Adipocytes; Aging; Animals; Anorexia; Award; Biometry; Body Weight; Body Weight decreased; Body fat; Boston; Caloric Restriction; Chronic; Class; Clinical Research; Communities; Condition; Consumption; Culture Media; DEXA; Daily; Desire for food; Development; Diet; Dietary Intervention; Elderly; Elevation; Endocrinology; Energy Intake; Energy Metabolism; Enrollment; Faculty; Failure; Fasting; Fellowship; Functional disorder; Future; Genetic Transcription; Geriatrics; Goals; Health Status; Height; Homeostasis; Hormones; Hour; Human; Individual; Inflammatory; Injury; Interleukin-6; Internist; Intervention Studies; Knowledge; Laboratories; Lead; Leptin; Lipopolysaccharides; Measurement; Mediator of activation protein; Medical center; Medicine; Mentors; Messenger RNA; Metabolism; Monitor; Morbidity - disease rate; Peripheral Blood Mononuclear Cell; Phase; Physicians; Physiological; Pilot Projects; Plasma; Population; Prevention; Prevention intervention; Principal Investigator; Production; Protocols documentation; Public Health Schools; Radioimmunoassay; Recovery; Regulation; Relative (related person); Reporting; Research; Research Personnel; Resources; Rest; Reverse Transcriptase Polymerase Chain Reaction; Risk; Satiation; Scanning; Scientist; Source; Testing; Time; Universities; Washington; Week; Weight; Work; aged; autocrine; base; career; cohort; cytokine; energy balance; experience; functional decline; instructor; macrophage; member; mortality; prevent; programs; prospective; research and development; research study; response; skills; therapy development; young adult

DESCRIPTION (provided by applicant): Dr Michi Yukawa completed her geriatric fellowship at the University of Washington (UW) in June 2000, and she is an Acting Instructor within the Division of Gerontology and Geriatric Medicine (DGGM) at the UW. Prior to her geriatric fellowship, she practiced in Boston MA for five years as an internist. The K-23 Award will give Dr Yukawa time and resources to acquire knowledge and technical skills to become an independent physician scientist. Dr Itamar B Abrass will guide her career development within Geriatric Medicine. Dr D Scott Weigle will be her research mentor and supervise her laboratory work and development of research protocols. Additional faculty members in the DGGM and the Department of Endocrinology of the UW will provide further guidance. She will attend advanced classes in biostatistics at the School of Public Health of the UW. Controlled dietary intervention and physiologic studies will be performed at the Clinical Research Center (CRC) of the University of Washington Medical Center (UWMC). The long-term objective of her research is to determine the underlying pathophysiology of involuntary weight loss and anorexia in the geriatric population. Understanding energy regulation and metabolism in healthy older adults is necessary prior to investigating older adults with involuntary weight loss and anorexia. Previous studies have reported dysregulation of energy intake in older subjects after calorie restriction. Other studies have suggested abnormalities in leptin homeostasis in older adults. Therefore, the specific aims of the proposed project are to test the hypothesis that elevated pro-inflammatory cytokines lead to elevated leptin levels in older adults, which in turn are associated with inability of older adults to recover after a period of moderate caloric restriction. 1) A cross-sectional comparison of healthy community dwelling older and younger adults before and after calorie restriction will be performed. 2) The same cohort of older subjects will be followed for two years to identify factors that predict weight loss in older adults. [3) The relationship between pro-inflammatory cytokines, leptin levels and involuntary weight loss in older adults will be investigated. Pro-inflammatory cytokines secreted from adipocytes of older adults with and without weight loss and healthy younger subjects will be compared. Leptin levels in culture media will be analyzed by radioimmunoassay, and leptin mRNA in adipocytes will be analyzed by real time RT-PCR. The goal of these studies is to define the relationship of pro-inflamlnatory cytokines and leptin levels to body weight regulation in older adults.]

描述（由申请人提供）：Michi Yukawa博士于2000年6月在华盛顿大学（UW）完成了她的老年学研究金，她是UW老年学和老年医学部（DGGM）的代理讲师。在她的老年奖学金之前，她在马萨诸塞州波士顿实习了五年的内科医生。K-23奖将为汤川博士提供时间和资源，以获得知识和技术技能，成为一名独立的医生科学家。Itamar B Abrass博士将指导她在老年医学领域的职业发展。D Scott Weigle博士将成为她的研究导师，并监督她的实验室工作和研究方案的制定。DGGM和华盛顿大学内分泌学系的其他教职员工将提供进一步的指导。她将参加华盛顿大学公共卫生学院的生物统计学高级课程。对照饮食干预和生理学研究将在华盛顿大学医学中心（UWMC）的临床研究中心（CRC）进行。她的研究的长期目标是确定老年人群中非自愿体重减轻和厌食症的潜在病理生理学。了解健康老年人的能量调节和代谢是必要的，然后再调查老年人与非自愿减肥和厌食症。先前的研究报告了热量限制后老年受试者的能量摄入失调。其他研究表明，老年人的瘦素稳态异常。因此，拟议项目的具体目的是检验这一假设，即促炎细胞因子升高导致老年人瘦素水平升高，这反过来又与老年人在适度限制热量一段时间后无法恢复有关。1)将对健康社区居住的老年人和年轻人在热量限制前后进行横断面比较。2)同一队列的老年受试者将被随访两年，以确定预测老年人体重减轻的因素。 [3)促炎细胞因子，瘦素水平和老年人的体重不自主下降之间的关系将进行调查。将比较有和没有体重减轻的老年人和健康的年轻受试者的脂肪细胞分泌的促炎细胞因子。将通过放射免疫测定法分析培养基中的瘦素水平，并通过真实的时间RT-PCR分析脂肪细胞中的瘦素mRNA。这些研究的目的是确定促炎细胞因子和瘦素水平与老年人体重调节的关系。

项目成果

Body mass index and C-reactive protein in the healthy Korean aged men.

韩国健康老年男性的体重指数和 C 反应蛋白。

• DOI: 10.3346/jkms.2006.21.5.811
• 发表时间: 2006
• 期刊: Journal of Korean medical science
• 影响因子: 4.5
• 作者: Won,ChangWon;Lee,SangWon;Choi,HyunRim;Kim,ByungSung;Park,HyeSoon;Yukawa,Michi
• 通讯作者: Yukawa,Michi

Leptin levels recover normally in healthy older adults after acute diet-induced weight loss.

健康老年人在急性饮食引起的体重减轻后，瘦素水平会正常恢复。

• DOI: 10.1007/bf03008277
• 发表时间: 2008
• 期刊: The journal of nutrition, health & aging
• 作者: Yukawa,M;Phelan,EA;Callahan,HS;Spiekerman,CF;Abrass,IB;Weigle,DS
• 通讯作者: Weigle,DS

Peripheral ghrelin treatment stabilizes body weights of senescent male Brown Norway rats at baseline and after surgery.

外周生长素释放肽治疗可稳定衰老雄性棕色挪威大鼠在基线和手术后的体重。

• DOI: 10.1152/ajpregu.00035.2008
• 发表时间: 2008
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Yukawa,Michi;Weigle,DavidS;Davis,CharlesD;Marck,BrettT;Wolden-Hanson,Tami
• 通讯作者: Wolden-Hanson,Tami