Effects of Nicotine in Smokers with Anxious Mood

尼古丁对焦虑情绪吸烟者的影响

• 批准号: 6601991
• 负责人: Sandra B. Morissette
• 金额: $ 12.34万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-25 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6601991
• 关键词: anxiety disorders; behavioral /social science research tag; clinical research; comorbidity; cues; emotions; human subject; imagery; nicotine; nicotine replacement; patient oriented research; placebos; psychology; psychometrics; questionnaires; smoking; tobacco abuse; transdermal drug delivery

DESCRIPTION (provided by applicant): This request for a Mentored Patient-Oriented Research Career Development Award (K23) is made by Dr. Sandra Baker-Morissette to foster her academic and research career development as a clinical scientist in smoking, nicotine dependence and psychiatric comorbidity. Dr. Baker-Morissette's career development plan spans 5 years, during which she will continue to work closely with her sponsor, Dr. Gulliver, as well as her co-mentors, Drs. David Barlow, David Spiegel, and Stephen Tiffany. Statistical consultation will be provided by the Boston University School of Medicine. Her career plan includes individual meetings with each mentor, mentorship team meetings, and coursework in statistical analysis and ethics. Her short-term goals are to expand upon her theoretical, methodological, and statistical skills needed to become a highly productive clinical scientist and to develop an independent programmatic line of research. Dr. Baker-Morissette's plan should yield sufficient experience as defined by data collection, grant writing, and paper presentations to advance by the close of the award to Associate Professor. Dr. Baker-Morissette's overarching ambition is to make a meaningful contribution to the knowledge base on tobacco use and comorbid anxiety disorders across the lifespan. Her personal career goal is to progress to Full Professor within the Medical School of Boston University. The proposed study expands on Dr. Baker-Morissette's initial studies of anxiety and tobacco use research by examining the effects of nicotine and mood cue exposure on smoking urge and anxiety in cigarette smokers who have comorbid anxiety disorders. In a between- and within-subjects design, smokers will receive a nicotine (21 mg) or placebo patch in a counterbalanced order across two assessment days. During each assessment day, they will engage in a series of imaginal cue exposures that vary in content: smoking plus anxiety cues, smoking cues alone, anxiety cues alone, and neutral cues. Participants will complete self-report questionnaires prior to and following each exposure, including measures of smoking urge and anxiety. Understanding the effects of nicotine on smoking urge in a psychiatric population is particularly important in light of the difficulty that smokers with psychiatric comorbidity have with quitting smoking. Knowledge of such factors may assist our understanding of conditions that influence the relapse process, as well as the effect of certain cues on smoking urge when individuals are attempting to quit smoking and simultaneously using transdermal nicotine replacement therapy. In sum, this research will foster the career development of Dr. Baker- Morissette, and ensure the next step of her programmatic research, which has an excellent probabilit3-to increase our understanding of the links between nicotine, negative affect and tobacco use disorder.

描述（由申请人提供）： Sandra Baker-Morissette博士提出了这一要求，以指导患者为导向的研究职业发展奖（K23），以促进她作为吸烟，尼古丁依赖和精神病并发症临床科学家的学术和研究职业发展。Baker-Morissette博士的职业发展计划跨越5年，在此期间，她将继续与她的赞助商Gulliver博士以及她的共同导师大卫巴洛博士、大卫斯皮格尔博士和斯蒂芬蒂芙尼博士密切合作。波士顿大学医学院将提供统计咨询。她的职业规划包括与每位导师的单独会议，导师团队会议，以及统计分析和道德方面的课程。她的短期目标是扩大她的理论，方法和统计技能，成为一个高产的临床科学家，并开发一个独立的研究项目线。贝克-莫里塞特博士的计划应该产生足够的经验，如数据收集，赠款写作和论文演示所定义的，以推进到副教授奖结束。Baker-Morissette博士的首要目标是为整个生命周期的烟草使用和共病焦虑症的知识基础做出有意义的贡献。她的个人职业目标是晋升为波士顿大学医学院的正教授。这项拟议中的研究扩展了贝克-莫里塞特博士对焦虑和烟草使用研究的初步研究，通过检查尼古丁和情绪线索暴露对患有焦虑症的吸烟者的吸烟欲望和焦虑的影响。在受试者间和受试者内设计中，吸烟者将在两个评估日内以平衡顺序接受尼古丁（21 mg）或安慰剂贴剂。在每个评估日，他们将参与一系列内容不同的想象线索暴露：吸烟加焦虑线索，单独吸烟线索，单独焦虑线索和中性线索。参与者将在每次暴露之前和之后完成自我报告问卷，包括吸烟欲望和焦虑的测量。了解尼古丁对精神病人群吸烟冲动的影响尤其重要，因为患有精神病合并症的吸烟者难以戒烟。这些因素的知识可能有助于我们了解影响复吸过程的条件，以及当个体试图戒烟并同时使用经皮尼古丁替代疗法时某些线索对吸烟冲动的影响。总之，这项研究将促进Baker- Morissette博士的职业发展，并确保她的计划性研究的下一步，这有很好的可能性3-增加我们对尼古丁，负面影响和烟草使用障碍之间联系的理解。