Effects of Nicotine in Smokers with Anxious Mood

尼古丁对焦虑情绪吸烟者的影响

• 批准号: 6805664
• 负责人: Sandra B. Morissette
• 金额: $ 12.78万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-25 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6805664
• 关键词: anxiety disorders; behavioral /social science research tag; clinical research; comorbidity; cues; emotions; human subject; imagery; nicotine; nicotine replacement; patient oriented research; placebos; psychology; psychometrics; questionnaires; smoking; tobacco abuse; transdermal drug delivery

DESCRIPTION (provided by applicant): This request for a Mentored Patient-Oriented Research Career Development Award (K23) is made by Dr. Sandra Baker-Morissette to foster her academic and research career development as a clinical scientist in smoking, nicotine dependence and psychiatric comorbidity. Dr. Baker-Morissette's career development plan spans 5 years, during which she will continue to work closely with her sponsor, Dr. Gulliver, as well as her co-mentors, Drs. David Barlow, David Spiegel, and Stephen Tiffany. Statistical consultation will be provided by the Boston University School of Medicine. Her career plan includes individual meetings with each mentor, mentorship team meetings, and coursework in statistical analysis and ethics. Her short-term goals are to expand upon her theoretical, methodological, and statistical skills needed to become a highly productive clinical scientist and to develop an independent programmatic line of research. Dr. Baker-Morissette's plan should yield sufficient experience as defined by data collection, grant writing, and paper presentations to advance by the close of the award to Associate Professor. Dr. Baker-Morissette's overarching ambition is to make a meaningful contribution to the knowledge base on tobacco use and comorbid anxiety disorders across the lifespan. Her personal career goal is to progress to Full Professor within the Medical School of Boston University. The proposed study expands on Dr. Baker-Morissette's initial studies of anxiety and tobacco use research by examining the effects of nicotine and mood cue exposure on smoking urge and anxiety in cigarette smokers who have comorbid anxiety disorders. In a between- and within-subjects design, smokers will receive a nicotine (21 mg) or placebo patch in a counterbalanced order across two assessment days. During each assessment day, they will engage in a series of imaginal cue exposures that vary in content: smoking plus anxiety cues, smoking cues alone, anxiety cues alone, and neutral cues. Participants will complete self-report questionnaires prior to and following each exposure, including measures of smoking urge and anxiety. Understanding the effects of nicotine on smoking urge in a psychiatric population is particularly important in light of the difficulty that smokers with psychiatric comorbidity have with quitting smoking. Knowledge of such factors may assist our understanding of conditions that influence the relapse process, as well as the effect of certain cues on smoking urge when individuals are attempting to quit smoking and simultaneously using transdermal nicotine replacement therapy. In sum, this research will foster the career development of Dr. Baker- Morissette, and ensure the next step of her programmatic research, which has an excellent probabilit3-to increase our understanding of the links between nicotine, negative affect and tobacco use disorder.

描述(由申请人提供)： 桑德拉·贝克-莫里塞特博士要求设立以患者为导向的研究职业发展奖(K23)，以促进她作为吸烟、尼古丁依赖和精神疾病方面的临床科学家的学术和研究职业发展。贝克-莫里塞特博士的职业发展计划跨越5年，在此期间，她将继续与她的赞助人格列佛博士以及她的共同导师大卫·巴洛博士、大卫·斯皮格尔博士和斯蒂芬·蒂凡尼博士密切合作。波士顿大学医学院将提供统计咨询。她的职业规划包括与每位导师的个人会议、导师团队会议，以及统计分析和伦理学方面的课程。她的短期目标是扩展她的理论、方法和统计学技能，成为一名高生产率的临床科学家，并发展一条独立的研究计划线。贝克-莫里塞特博士的计划应该提供足够的经验，如数据收集、助学金撰写和论文演示文稿所定义的那样，以便在副教授获奖结束时取得进展。贝克-莫里塞特博士的首要目标是为烟草使用和终生共病焦虑症的知识库做出有意义的贡献。她的个人职业目标是晋升为波士顿大学医学院的正教授。这项拟议的研究扩展了贝克-莫里塞特博士关于焦虑和烟草使用研究的最初研究，考察了尼古丁和情绪线索暴露对患有焦虑症的吸烟者吸烟冲动和焦虑的影响。在受试者之间和受试者内部的设计中，吸烟者将在两个评估日内按平衡顺序获得尼古丁(21毫克)或安慰剂贴片。在每个评估日，他们将参与一系列内容不同的想象线索暴露：吸烟加焦虑线索，单独吸烟线索，单独焦虑线索，以及中性线索。参与者将在每次接触之前和之后完成自我报告问卷，包括吸烟冲动和焦虑的测量。考虑到患有精神疾病的吸烟者在戒烟方面的困难，了解尼古丁对精神人群中吸烟冲动的影响尤为重要。对这些因素的了解可能有助于我们了解影响复发过程的条件，以及当个人试图戒烟并同时使用经皮尼古丁替代疗法时，某些线索对吸烟冲动的影响。总而言之，这项研究将促进贝克-莫里塞特博士的职业发展，并确保她的下一步规划研究，这是一个极有可能的3-增加我们对尼古丁、负面影响和烟草使用障碍之间的联系的理解。