SYSTEMIC DISEASE EFFECT ON ORAL HEALTH IN ELDERLY

系统性疾病对老年人口腔健康的影响

• 批准号: 6606166
• 负责人: ELISA M GHEZZI
• 金额: $ 9.47万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6606166
• 关键词: age difference; aging; anticholinergic agent; clinical research; drug adverse effect; geriatrics; human middle age (35-64); human old age (65+); human subject; intravenous administration; oral health; quaternary ammonium compound; questionnaires; salivary glands; salivation; xerostomias; young adult human (21-34)

Candidate: The candidate has been involved in basic science, clinical, and epidemiological research throughout her undergraduate, pre-doctoral, and post-doctoral studies. This has resulted in a commitment to conduct patient-oriented research in order to better understand the health of the oral cavity in older adults and ultimately how to preserve oral function as people age. The immediate goal is to pursue intense training in multidisciplinary and collaborative settings with leaders in the fields of clinical research. The long-term goal is to become an independent clinical investigator who can combine expertise in geriatric dentistry with research protocols designed to identify connections between oral and systemic diseases and their treatments in the elderly. Environment: The University of Michigan provides an excellent setting for this program with its multidisciplinary approach to clinical research in geriatrics and its many training facilities. The General Clinical Research Center is world-renown for its clinical research advancements in the fields of medicine and dentistry. The School of Public Health has well established graduate training programs for health care professionals. Research rotations will take advantage of existing collaborations with other training locations: University of North Carolina, National Institutes of Health, and the Veterans Administration Medical Center in Ann Arbor. Research Career Development Plan: This multi-faceted plan spans the entire 5 year award period and includes a Masters in Science in Clinical Research Design and Statistical Analysis, supervised research rotations. and seminars on research responsibility, ethics, geriatric medicine and dentistry. Regular research evaluations are incorporated into each section of the program. Research Project: The overall theme is the investigation on the effects of systemic diseases and their treatments on oral health of the elderly. The first segment of the clinical research project focuses on the effect of anti-sialogogue medications on subjective and objective measures of salivary output in young and older subjects. This will be followed by investigating hypertension and its treatment on the oral cavity, conducting epidemiological surveys on the prevalence and severity of drug-induced salivary disorders among older adults, and ultimately the design of a protocol to prevent salivary disorders from causing oral diseases as a consequence of medication intake.

候选人：该候选人在本科，博士前和博士后研究期间一直参与基础科学，临床和流行病学研究。因此，我们致力于开展以患者为导向的研究，以更好地了解老年人的口腔健康状况，并最终了解如何随着年龄的增长保持口腔功能。近期目标是在多学科和协作环境中与临床研究领域的领导者进行密集培训。长期目标是成为一名独立的临床研究者，能够将老年牙科专业知识与旨在确定老年人口腔和全身疾病及其治疗之间联系的研究方案联合收割机相结合。工作环境：密歇根大学提供了一个很好的设置，这个程序与其多学科的方法，在老年医学和许多培训设施的临床研究。综合临床研究中心以其在医学和牙科领域的临床研究进展而闻名世界。公共卫生学院为医疗保健专业人员建立了良好的研究生培训计划。研究轮换将利用与其他培训地点的现有合作：北卡罗来纳州大学、美国国立卫生研究院和安阿伯的退伍军人管理局医疗中心。研究职业发展计划：这个多方面的计划跨越了整个5年的奖励期，包括临床研究设计和统计分析科学硕士学位，监督研究轮换。以及关于研究责任、伦理、老年医学和牙科的研讨会。定期研究评估被纳入该计划的每个部分。研究计划：整体主题为探讨全身性疾病及其治疗对长者口腔健康的影响。临床研究项目的第一部分重点是抗流涎药物对年轻和老年受试者唾液分泌的主观和客观测量的影响。随后将调查高血压及其对口腔的治疗，对老年人中药物引起的唾液腺疾病的患病率和严重程度进行流行病学调查，并最终设计一项方案，以防止唾液腺疾病因药物摄入而引起口腔疾病。