Acquisition of a Bruker 600MHz NMR Spectrometer

购买 Bruker 600MHz NMR 波谱仪

• 批准号: 6441144
• 负责人: DANZHOU YANG
• 金额: $ 39.3万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6441144
• 关键词: biomedical equipment purchase; chemical structure function; intermolecular interaction; nuclear magnetic resonance spectroscopy

This proposal requests a triple-resonance 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer, which will be located in the College of Pharmacy at the University of Arizona. Common features of the user grouip are (1) NIH supported research programs with a significant NMR component and (2) immediate need for high-field NMR instrumentation not available in the proximity of the College of Pharmacy (all users are located in the College of Pharmacy). Most major users have just relocated to the University of Arizona, and access to a high-field NMR spectrometer is critical to the maximum productivity and success of these projects.

该提案要求三重共振600 MHz核磁共振（NMR）光谱仪，将位于亚利桑那大学药学院。 用户组的共同特点是（1）NIH支持的研究计划与一个显着的NMR组件和（2）迫切需要高场NMR仪器无法在药学院附近（所有用户都位于药学院）。大多数主要用户刚刚搬迁到亚利桑那大学，获得高场NMR光谱仪对于这些项目的最大生产力和成功至关重要。

项目成果

Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.

• DOI: 10.1007/128_2012_333
• 发表时间: 2013
• 期刊: TOPICS IN CURRENT CHEMISTRY
• 影响因子: 8.6
• 作者: Kaiser, Christine E.;Gokhale, Vijay;Yang, Danzhou;Hurley, Laurence H.
• 通讯作者: Hurley, Laurence H.

Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design.

• DOI: 10.1021/ja205646q
• 发表时间: 2011-11-09
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Dai, Jixun;Carver, Megan;Hurley, Laurence H.;Yang, Danzhou
• 通讯作者: Yang, Danzhou

Structural insights into G-quadruplexes: towards new anticancer drugs.

• DOI: 10.4155/fmc.09.172
• 发表时间: 2010-04
• 期刊: Future medicinal chemistry
• 影响因子: 4.2
• 作者: Yang D;Okamoto K
• 通讯作者: Okamoto K

Sequence, stability, and structure of G-quadruplexes and their interactions with drugs.

• DOI: 10.1002/0471142700.nc1705s50
• 发表时间: 2012-09
• 期刊: Current protocols in nucleic acid chemistry
• 作者: Chen, Yuwei;Yang, Danzhou
• 通讯作者: Yang, Danzhou

c-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability.

• DOI: 10.1093/nar/gkr612
• 发表时间: 2011-11-01
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Mathad RI;Hatzakis E;Dai J;Yang D
• 通讯作者: Yang D