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15 Tesla Magnet for Micro MRI and Magenetic Levitation

用于微型 MRI 和磁悬浮的 15 特斯拉磁铁

基本信息

批准号：
6440801
负责人：
BRUCE E HAMMER
金额：
$ 50万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-05-01 至 2005-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6440801
关键词：
biomedical equipment purchase magnetic resonance imaging superconductivity

项目摘要

The goal of this proposal is to charge a dual-purpose 15 Tesla/50mm warm-bore superconductive NMR magnet to levitate diamagnetic materials for extended times and support high field MR microscopy imaging applications. To the best of our knowledge this will be the first conductive magnet capable of levitating biological samples. There are resistive magnets available, however, operating costs are on the order of $13,000/day for electricity and water. The proposed magnet will cost about $25/day in cryogen consumption. Furthermore, there is no other instrument in the world with the dual capability of MRI and levitation. This instrument will reside at the Center for Interdisciplinary Applications for Magnetic Resonance (CIA-MR) at the University of Minnesota Twin Cities Campus. The CIA-MR staff presently maintains home-built 1.5 T/680 mm and 5.0 T/ 40 mm MRI systems that support biomedical, engineering and physical science research applications. The proposed magnet is similar to high-field NMR spectroscopic magnets, however, the magnet design incorporates a very strong field gradient (approximately 100 T/m) near the top of the cryostat which is necessary for magnetic levitation. Levitation occurs when the magnetic force counterbalances the gravitational force and thus simulates orbital freefall. The geometric center of the magnet has sufficient field homogeneity for MR microimaging applications. This instrument will provide a unique environment to process organic and inorganic materials and investigate biological materials, living and non-living, in a simulated microgravity environment. The levitation aspect of the magnet will e used by a consortium of academic and industrial scientists for the implementation of new types of materials; containerless processing of molten oxide materials; measurement of cell growth and gene expression; and growth of engineered tissues. MR micro imaging applications will focus on hollow fiber bioreactor (HFBR) microstructure and cell metabolism, bone growth and remodeling around orthopedic implants and measurement of cryoprotectant transport in hepatocyte spheroids. This instrument will be available to a consortium of scientists form the University of Minnesota (Minneapolis, MN), Mayo Clinic (Rochester, MN), Minnesota Medial Research Foundation (Minneapolis) and Containerless Research, Inc (Evanston, IL). NIH funded grant swill consume approximately 80% of magnet use. This instrument will also integrate into a number of graduate and undergraduate science and engineering courses taught at the University of Minnesota. The goal is to promote hands-on experiments in a high magnetic field/high magnetic field gradient system for students, faculty and industrial partners.

该提案的目标是充电一个双重用途的15特斯拉/50毫米暖孔超导核磁共振磁体，使抗磁性材料悬浮更长时间，并支持高场磁共振显微镜成像应用。据我们所知，这将是第一个能够悬浮生物样本的导电磁铁。虽然有电阻磁体可用，但每天的电费和水费约为13 000美元。拟议的磁体将花费约25美元/天的冷冻消耗。此外，目前世界上还没有其他仪器同时具备MRI和悬浮的双重功能。该仪器将驻留在明尼苏达大学双城校区的磁共振跨学科应用中心（CIA-MR）。CIA-MR工作人员目前维护着支持生物医学、工程和物理科学研究应用的国产1.5 T/680毫米和5.0 T/ 40毫米MRI系统。所提出的磁体类似于高场核磁共振光谱磁体，然而，磁体设计在低温恒温器顶部附近包含一个非常强的场梯度（约100 T/m），这是磁悬浮所必需的。当磁力抵消重力时，就会产生悬浮，从而模拟轨道自由落体。磁体的几何中心具有足够的磁场均匀性，适用于磁共振微成像应用。该仪器将提供一个独特的环境来处理有机和无机材料，并在模拟微重力环境中研究生物材料，包括生物和非生物。一个由学术和工业科学家组成的联盟将利用磁铁的悬浮方面来实施新型材料；熔融氧化物材料无容器处理；细胞生长和基因表达的测定；以及工程组织的生长。磁共振微成像的应用将集中在中空纤维生物反应器（HFBR）的微观结构和细胞代谢、骨科植入物周围的骨骼生长和重塑以及肝细胞球体中冷冻保护剂运输的测量。该仪器将提供给明尼苏达大学（Minneapolis， MN）、梅奥诊所（Rochester， MN）、明尼苏达医学研究基金会（Minneapolis）和Containerless Research， Inc （Evanston， IL）的科学家联盟。美国国立卫生研究院资助的拨款消耗了大约80%的磁铁使用。该仪器还将整合到明尼苏达大学的一些研究生和本科生的科学和工程课程中。目标是促进学生，教师和工业合作伙伴在高磁场/高磁场梯度系统中的动手实验。