HUMAN OTOLITH-OCULAR RESPONSES

人类耳石-眼睛反应

• 批准号: 6642902
• 负责人: Joseph M Furman
• 金额: $ 34.88万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6642902
• 关键词: cerebellar disorders; clinical research; eye movements; head movements; human subject; neural information processing; otocyst /otolith; proprioception /kinesthesia; saccades; smooth pursuit eye movement; vestibuloocular reflex; visual stimulus

The primary goal of this subproject is to characterize the otolith-ocular responses elicited by off-vertical axis rotation (OVAR) in normal, peripheral lesioned, and central lesioned humans. The eye movement responses will be obtained with dual scleral search coils during per-rotatory and post-rotatory periods of OVAR using three-dimensional measurement techniques that have recently been incorporated into the P.I.?s laboratory. A second major goal is to characterize the interaction between vestibular stimulation and volitional eye movements in normal human subjects, with the ultimate objective to determine if vestibular disturbances produce deficits in visual-vestibular interactions. The first specific aim consists of two parts. First, the subproject seeks to determine if the reorientation of the eye rotation vector that is aligned with gravity during OVAR post-rotatory responses will be asymmetric in peripheral lesioned patients. In normal primates, the slow phase eye velocity during OVAR post-rotatory responses re-orients to be aligned with gravity regardless of head position due to inertial otolith signals. In nerve lesioned patients, it is hypothesized that the reorientation will be reduced or absent when the lesioned ear is placed downward. Second, the subproject will address whether the per-rotatory OVAR responses have abnormal eye movement components in lesioned patients as compared to normals. The second specific aim will use the same testing conditions for per- and post-rotatory OVAR responses in cerebellar damaged patients to examine possible differences in eye rotation vector re-orientation and 3-D otolith ocular reflex organization. The third specific aim will examine saccadic and smooth pursuit eye movements made during concurrent head rotations. The three dimensional organization of these volitional eye movements will be characterized during both earth-vertical axis and constant velocity OVAR rotations to compare canal versus otolith visual-vestibular interactions.

这个子项目的主要目标是描述 耳石眼反应引起的离垂直轴旋转（OVAR）， 正常人、外周病变人和中枢病变人。眼球运动 在旋转期间将使用双巩膜搜索线圈获得响应 使用三维测量技术测量OVAR的后旋转周期 最近被纳入私家侦探的名单的实验室。第二主 目的是描述前庭刺激和 正常人受试者的意志性眼球运动，最终目标是 以确定前庭障碍是否会导致视觉-前庭功能障碍， 交互. 第一个具体目标包括两个部分。首先，该次级项目力求 确定与所述眼睛旋转矢量对准的所述眼睛旋转矢量的所述重定向是否 OVAR旋转后反应期间的重力将在外周不对称 患者的损伤。在正常灵长类动物中，OVAR过程中的慢相眼速度 旋转后反应重新定向以与重力对齐，而不管头部 位置由于惯性耳石信号。在神经损伤患者中， 假设当病变发生时， 耳朵向下。第二，该子项目将解决是否每轮 OVAR反应在病变中具有异常的眼动成分 患者与正常人相比。第二个具体目标将使用相同的 小脑中旋转前和旋转后OVAR反应的测试条件 受损患者检查眼球旋转向量重定向的可能差异 和三维耳石眼反射组织。第三个具体目标 我将检查在同时进行的扫视和平滑追踪眼球运动， 头部旋转。这些意志之眼的三维结构 运动的特点将在地球垂直轴和常数 速度OVAR旋转比较耳道与耳石视觉-前庭 交互.