CERVICAL INFLUENCES ON BALANCE

描述（由申请人提供）：前庭、本体感受和视觉 输入由中枢神经系统整合，以产生适当的 眼运动和姿势反应。颈部传入神经提供了独特的 信息，使头部参考信号从视觉和前庭 系统将被转换为中继参考信号。许多患者的 平衡障碍注意到头晕恶化与 颈部不适。这种联系的基础尚不清楚。长期 本研究的目的是开发一种合理的诊断方法 颈源性头晕和颈部影响的评估 前庭障碍这三个具体目标的探索 一项研究建议涉及提高我们对宫颈影响的认识 总的来说特别地，本文提出的实验的目标是 生成关于宫颈影响的客观测量的可检验假设 前庭-眼和前庭-脊髓反应，以及视觉诱导的 姿势摇摆本提案的具体目的是探讨三种不同的 颈椎对平衡的影响：1.横摇头对躯干的影响 在Listing平面相对于头部的方向上的位置， 2.偏航头对躯干位置对人体姿势摇摆的影响 正弦耳间前庭电刺激，和3.的影响 头-躯干侧偏位对鼻-枕视神经诱发的姿势摇摆的影响 流为了解决特定目标#1，将三维眼睛位置 在使用双巩膜的头部和躯干滚动倾斜的各种组合期间监测 搜索线圈为了解决具体目标#2， 正弦、双极、双耳前庭电刺激，在几次偏航期间 将测量头对躯干的位置。为了解决具体目标#3，姿势 将在虚拟脑内测量响应于鼻枕部光流的摇摆 在几个偏航头对躯干位置期间的真实环境。

DESCRIPTION (provided by applicant): Vestibular, proprioceptive and visual inputs are integrated by the central nervous system to produce appropriate ocular motor and postural responses. Cervical afferents provide unique information that enable head-referenced signals from the visual and vestibular systems to be transformed into trunk-referenced signals. Many patients with balance disorders note an association between a worsening of their dizziness and neck discomfort. The basis for this association is unknown. The long-term objective of this research is to develop a rational approach to the diagnosis of cervicogenic dizziness and to the assessment of cervical influences on vestibular disorders. Each of the three specific aims of this exploratory research proposal relates to improving our understanding of cervical influences on balance. In particular, the goal of the experiments proposed herein is to generate testable hypotheses regarding objective measures of cervical influences on vestibulo-ocular and vestibular-spinal responses, and on visually induced postural sway. The specific aims of this proposal are to explore three different aspects of the cervical influences on balance: 1. The influence of roll head-on-trunk position on the orientation of Listing's plane with respect to the head, 2. The influence of yaw head-on-trunk position on postural sway induced by sinusoidal interaural galvanic vestibular stimulation, and 3. The influence of yaw head-on-trunk position on postural sway induced by naso-occipital optic flow. To address specific aim #1, three-dimensional eye positions will be monitored during various combinations of head and trunk roll tilt using dual-scleral search coils. To address specific aim #2, postural sway induced by sinusoidal, bipolar, binaural galvanic vestibular stimulation during several yaw head-on-trunk positions will be measured. To address specific aim #3, postural sway will be measured in response to naso-occipital optic flow within a virtual reality environment during several yaw head-on-trunk positions.