CORE--BIOSTATISTICS AND DATA MANAGEMENT

核心C是这个PPG的新核心。以前，统计相关服务是通过行政核心核心A向PPG调查员提供的。由于对此类服务的需求增加，Core C现在是一个独立的核心。核心C将主要关注生物统计学和数据管理（BDM），包括测量。然而，Core C还包含了“建模”和图像分析的分析组件。我们的目标是确保将适当的统计专业知识集成到每个项目中，从开始（例如，设计，功率分析），到实现（例如，测量评估），到完成（统计分析，解释和报告）。Core C将提供以下服务：协助研究的设计。BDM团队的一个主要目标是使研究人员在开始其主要项目或新的子项目之前获得有关实验设计的建议。2. 管理ppg生成的所有数据的电子数据库，确保安全存储和备份，确保输入的质量和准确性，并及时提供数据文件以供后续分析。3. 与研究人员和核心合作，评估和维护PPG中使用的测量的可靠性和有效性。4. 协助识别、获取和使用软件进行统计分析和相关任务。5. 对调查人员自行选择的统计程序的选择、实施和解释进行协商。6. 根据需要进行更复杂的统计分析（如模拟研究、混合模型）。7. 合作编写手稿的统计和有关方面。8. 促进更大的发展和使用建模和图像分析程序方面的专门知识。包括5名博士在内的8名科学家统计数据分析师将通过Core c提供支持。依靠一支具有不同专业领域的统计数据分析师团队，我们可以支持几乎任何统计分析领域的项目。

Core C is a new core to this PPG. Previously, statistically related services were offered to PPG investigators through Core A, the administrative core. Core C is now an independent core, due to increased demand for such services. Core C will focus primarily on biostatistics and data management (BDM) including measurement. However, Core C also incorporates analytical components of "modeling" and image analysis. Our objective is to insurer that appropriate statistical expertise is integrated into each project from inception (e.g., design, power analysis), to implementation (e.g., measurement evaluation), to completion (statistical analysis, interpretation, and reporting). Core C will provide the following services: 1. Assistance in the design of studies. A major goal of the BDM team is to enable investigators to obtain advise on experimental design before they begin their primary projects or new sub-projects. 2. Management of an electronic database of all PPG-generated data, ensuring secure storage and back up, quality and accuracy of entry, and timely provision of data files for subsequent analyses. 3. Collaboration with investigators and Core in evaluating and maintaining the reliability and validity of measured used in the PPG. 4. Assistance in identifying, obtaining, and using software for statistical analysis and related tasks. 5. Consultation on the choice, implementation, and interpretation of statistical procedures that investigators choose to conduct themselves. 6. Conduct of more complex statistical analyses as needed (e.g. simulation studies, mixed models). 7. Collaboration on preparing statistical and related aspects of manuscripts. 8. Fostering greater development and use of expertise in modeling and image analysis procedures. Eight scientists including five Ph.D. statistician-data analysts will provide support through Core C. By relying on a team of statistician-data analysts with diverse areas of specialization, we can support the projects in virtually any area of statistical analysis.