FEASIBILITY OF BORON NEUTRON CAPTURE THERAPY USING PARTICLE ACCELERATOR

脑肿瘤的硼中子俘获疗法（BNCT） 在BNL进行的临床试验中使用了来自医疗反应堆的过滤光束。 不幸的是，美国几乎没有可用的反应堆。S.这 可用于治疗，特别是在现有的 医院，而且几乎没有建造新医院的前景，特别是 靠近大型人口中心。 如果一个小型质子加速器 产生中子被认为是可以接受的，那么BNCT可以成为 一个容易获得的临床程序，因为困难， 选址将大大减少。 本研究将探讨 用加速器为BNCT产生中子的可行性， 比使用反应堆要好。 重点是目标的设计 用于产生中子和慢化剂的设计，以优化 中子产额和能谱，并尽量减少剂量 伽马射线的贡献。

Boron Neutron Capture Therapy (BNCT) of brain tumors is in clinical trials at BNL using a filtered beam from the Medical Reactor. Unfortunately, there are few available reactors in the U. S. which could be used to provide treatment, especially near existing hospitals, and little prospect of constructing new ones, particularly near large population centers. If a small proton accelerator to produce the neutrons is found to be acceptable, then BNCT could become a readily available clinical procedure since the difficulties in siting would be greatly reduced. This study will investigate the feasibility of producing neutrons for BNCT with an accelerator rather than with a reactor. The major emphasis is the design of the targets used to produce the neutrons and moderator designs to optimize the neutron yield and energy spectrum and to minimize the dose contribution from gamma rays.