AIRWAY PROTECTION DURING VOMITING

呕吐期间的气道保护

• 批准号: 6571531
• 负责人: IVAN M LANG
• 金额: $ 7.89万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6571531
• 关键词: biomechanics; cats; decerebration; dogs; emesis; esophagus; larynx muscle; muscle contraction; neuromuscular function; neuroregulation; reflux esophagitis; respiratory airway clearance; respiratory muscles; sedative /hypnotic; sensorimotor system; sensory receptors

Vomiting is a complex motor behavior that requires the coordinated action of musculature within the gastrointestinal and aerodigestive tracts. The mechanisms of airway protection during vomiting have not been studied and are presently unknown. This is in contrast to an extensive body of literature providing information on airway protective mechanisms operational during swallowing. Acute and chronic animal models will be utilized to study the role of the laryngeal, pharyngeal and hyoid muscles during vomiting. Investigation of the associated movements of the tongue base, hyoid bone, cricoid and thyroid cartilage, and epiglottis will also be studied. The action of these aerodigestive muscles will be temporally correlated with the action of the esophagus and gastrointestinal tract, and lower respiratory musculature. Finally, the relative contribution of peripheral reflexes and direct central nervous system control over the motor events that comprise vomiting will be studied.

呕吐是一种复杂的运动行为，需要协调 胃肠道和空气消化系统中的肌肉活动。这个 呕吐时的呼吸道保护机制还没有研究过，而且 目前还不得而知。这与大量的文学作品形成鲜明对比。 提供有关在以下时间运行的呼吸道保护机制的信息 吞下去。将利用急性和慢性动物模型来研究这种作用。 呕吐时喉部、咽部和舌骨的肌肉。调查 舌根、舌骨、环状软骨和甲状腺的相关运动 软骨和会厌也将被研究。这些人的行动 空气消化肌肉将在时间上与 食道和胃肠道，以及下呼吸道肌肉。 最后，外周反射和直接中枢反射的相对贡献 神经系统对包括呕吐的运动事件的控制将是 学习。