EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
基本信息
- 批准号:6564051
- 负责人:
- 金额:$ 16.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-01-01 至 2002-12-31
- 项目状态:已结题
- 来源:
- 关键词:action potentials auditory threshold carboplatin chinchilla denervation ear hair cell ear pharmacology electrophysiology evoked potentials gamma aminobutyrate kainate neural information processing neuropharmacology neurotoxicology neurotoxins neurotransmitter antagonist perceptual maskings sensorineural hearing loss
项目摘要
A series of experiments are proposed which investigate the functional
consequence of either permanent inner hair cell (IHC) loss using
carboplatin or temporary degeneration of eight nerve fibers using kainic
acid. The experimental animal will be the chinchilla. Preliminary data
from this laboratory demonstrate different patters of changes in evoke
potential amplitude at varying locations in the auditory nervous system
following injection of carboplatin or application of kainic acid to the
round window. We will survey outer hair cell integrity by recording
distortion product otoacoustic emissions from the early canal of each
animal. Following baseline studies, we will evaluate the time course of
the functional consequence of carboplatin and kainic acid on the responses
from the eighth nerve, inferior colliculus and auditory cortex. Using this
approach, we will investigate the role of IHC function on auditory
function and will study functional reorganization in the auditory system
in response to permanent IHC loss and transient deafferentation. Several
experiments will use GABA blockers to test the hypothesis that
disinhibition plays a role in compensatory changes seen in central
auditory structures following peripheral damage. A fundamental assumption
of this work is that a dissociation of peripheral and central effects of
ototoxic insults, or a differing time course of recovery is evidence of
compensatory functional reorganization.
提出了一系列研究功能的实验。
永久性内毛细胞(IHC)丢失的后果
卡铂或使用红藻氨酸的八种神经纤维的暂时性变性
酸。实验动物将是栗鼠。初步数据
从这个实验室展示了唤起的不同模式的变化
听觉神经系统不同位置的潜在波幅
在注射卡铂或应用海人酸后,
圆窗。我们将通过记录来调查外毛细胞的完整性
每个根管早期的失真产物耳声发射
动物。在基线研究之后,我们将评估以下时间进程
卡铂和红藻氨酸对反应的功能影响
来自第八神经、下丘和听觉皮质。使用这个
方法,我们将研究IHC功能对听觉的作用
功能,将研究听觉系统的功能重组
以应对永久性的IHC丢失和暂时性的去传入。几个
实验将使用GABA阻滞剂来检验这一假设
去抑制在中枢神经系统的代偿性变化中起作用
外周损伤后的听觉结构。一个基本的假设
这项工作的一个特点是,外周和中枢效应的分离
耳毒性侮辱,或不同的康复过程是证据
补偿性职能重组。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT BURKARD其他文献
ROBERT BURKARD的其他文献
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{{ truncateString('ROBERT BURKARD', 18)}}的其他基金
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
- 批准号:
6662127 - 财政年份:2002
- 资助金额:
$ 16.54万 - 项目类别:
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
- 批准号:
6410279 - 财政年份:2001
- 资助金额:
$ 16.54万 - 项目类别:
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
- 批准号:
6395820 - 财政年份:2000
- 资助金额:
$ 16.54万 - 项目类别:
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
- 批准号:
6397884 - 财政年份:2000
- 资助金额:
$ 16.54万 - 项目类别:
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
- 批准号:
6104517 - 财政年份:1999
- 资助金额:
$ 16.54万 - 项目类别:
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