HUMAN AND ANIMAL EVOKED POTENTIALS

人类和动物诱发电位

基本信息

  • 批准号:
    6267497
  • 负责人:
  • 金额:
    $ 17.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1998
  • 资助国家:
    美国
  • 起止时间:
    1998-06-01 至 1999-04-30
  • 项目状态:
    已结题

项目摘要

This project provides information that complements the data obtained in Projects 1 and 2 in humans and Projects 2, 3 and 4 in mice. This proposal hypothesize that the effects of aging on the processing of the central auditory nervous system will be manifested as changes in the temporal processing of stimuli and in the ability to process signals in noise. We propose that degradations in temporal processing with age reflect changes in the time course of synaptic events. Specifically, the slowing of synaptic events leads to the increases in the latencies and perhaps decreases in the amplitudes of the auditory evoked potentials due to a greater dispersion of post-synaptic potentials. From our auditory brainstem responses (ABR) data, it appears that temporal processing and simultaneous masking share a mechanism that appears to be neural (specifically, synaptic) in nature, and hence temporal dependencies of the ABR, such as rate and forward masking paradigms, may stress the same underlying processes that are stressed by an ipsilateral-direct masking paradigm. We will investigate the effects of aging in normal hearing young and old human adults using the ABR as the response measure. We will similarly test young-adult and middle-aged C57 mice, and young-adult, middle-aged and old CBA mice. The response measures will include both the ABR and near-field potentials recorded from the inferior colliculus. Using stimulus paradigms that stress synaptic mechanisms (e.g., rate, forward- masking and simultaneous-masking paradigms) and using dependent variables that are insensitive to peripheral hearing loss but sensitive to central auditory nervous system changes (e.g., the I-V interval in the human ABR), then it should be possible to isolate these measures that are sensitive to aging of the CANS.
本项目提供的信息是对中获得的数据的补充

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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ROBERT BURKARD其他文献

ROBERT BURKARD的其他文献

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{{ truncateString('ROBERT BURKARD', 18)}}的其他基金

EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
  • 批准号:
    6662127
  • 财政年份:
    2002
  • 资助金额:
    $ 17.42万
  • 项目类别:
HUMAN AND ANIMAL EVOKED POTENTIALS
人类和动物诱发电位
  • 批准号:
    6587592
  • 财政年份:
    2002
  • 资助金额:
    $ 17.42万
  • 项目类别:
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
  • 批准号:
    6564051
  • 财政年份:
    2002
  • 资助金额:
    $ 17.42万
  • 项目类别:
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
  • 批准号:
    6410279
  • 财政年份:
    2001
  • 资助金额:
    $ 17.42万
  • 项目类别:
HUMAN AND ANIMAL EVOKED POTENTIALS
人类和动物诱发电位
  • 批准号:
    6502859
  • 财政年份:
    2001
  • 资助金额:
    $ 17.42万
  • 项目类别:
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
  • 批准号:
    6395820
  • 财政年份:
    2000
  • 资助金额:
    $ 17.42万
  • 项目类别:
HUMAN AND ANIMAL EVOKED POTENTIALS
人类和动物诱发电位
  • 批准号:
    6299307
  • 财政年份:
    2000
  • 资助金额:
    $ 17.42万
  • 项目类别:
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
  • 批准号:
    6397884
  • 财政年份:
    2000
  • 资助金额:
    $ 17.42万
  • 项目类别:
EFFECTS OF CARBOPLATIN AND KAINIC ACID ON EVOKED RESPONSES
卡铂和红藻氨酸对诱发反应的影响
  • 批准号:
    6104517
  • 财政年份:
    1999
  • 资助金额:
    $ 17.42万
  • 项目类别:
HUMAN AND ANIMAL EVOKED POTENTIALS
人类和动物诱发电位
  • 批准号:
    6098287
  • 财政年份:
    1999
  • 资助金额:
    $ 17.42万
  • 项目类别:

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