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Integrating bioelectronics with cell membrane mimics in order to investigate the biological activity of drug molecules

将生物电子学与细胞膜模拟相结合以研究药物分子的生物活性

基本信息

批准号：
2266415
负责人：
金额：
--
依托单位：
University of Cambridge
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2266415
关键词：
Integrating bioelectronics cell membrane mimics

项目摘要

The characterisation of cell membranes and their protein components in the presence of small molecules is vital for biosensing and therapeutic applications. At Oxford, I pursued a Master's in computational biochemistry, investigating transmembrane protein interactions with small bioactive molecules at the Neuromuscular Junction with the aim of developing nerve agent antidotes. I have since performed research at Imperial College, becoming interested in the integration of molecular biology with material science and the multidisciplinary approach to research. For these reasons, I am naturally interested in Dr Owens' BEST group and their approach to combining biological systems with electronic devices for a whole range of applications. Organic electrochemical transistors (OECTs), using PEDOT:PSS as the conducting polymer, have the ability to seamlessly interface with biological systems and thus provide functional information about these systems in their native environments. OECTs are also able to provide high degrees of signal amplification and multiplexing for biosensing purposes. By integrating biological membrane mimics with OECTs, I intend to pursue research in the analysis of membranes and their components and in particular their protein components in response to environmental perturbations and interactions with small molecules. Such analysis could be applied to antimicrobial compound discovery, the study of drug resistance as well as broader biosensing applications.

在小分子存在的情况下，细胞膜及其蛋白质成分的表征对于生物传感和治疗应用至关重要。在牛津大学，我攻读了计算生物化学硕士学位，研究跨膜蛋白质与神经肌肉交界处的小生物活性分子的相互作用，目的是开发神经毒剂解毒剂。此后，我在帝国理工学院进行研究，对分子生物学与材料科学的结合以及多学科研究方法产生了兴趣。出于这些原因，我自然对欧文斯博士的BEST小组和他们将生物系统与电子设备相结合的方法感兴趣，以实现各种应用。有机电化学晶体管（OECTs）使用PEDOT:PSS作为导电聚合物，具有与生物系统无缝接口的能力，从而提供这些系统在其原生环境中的功能信息。oect还能够为生物传感目的提供高度的信号放大和多路复用。通过将生物膜模拟与OECTs相结合，我打算继续研究膜及其成分的分析，特别是膜的蛋白质成分对环境扰动和与小分子的相互作用的反应。这种分析可以应用于抗菌化合物的发现、耐药性的研究以及更广泛的生物传感应用。