Familial IgA Nephropathy: Genetic and Metabolic Studies

家族性 IgA 肾病：遗传和代谢研究

• 批准号: 6464953
• 负责人: JIRI F MESTECKY
• 金额: $ 131.18万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-15 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6464953
• 关键词: IgA nephropathy; clinical research; family genetics; glomerulonephritis; patient oriented research

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world. Because of its frequently unfavorable cou7rse and lack of specific therapy, IgAN represents a serious healthy care and economic problem. The overall objective of the proposed Program Project is to determine the genetic and molecular basis of this common disease through integrated studies of patients with IgAN or Henoch-Schonlein purpura (HSP), commonly considered the systemic form of the disease process causing IgAN. We will enroll 20 multiplex families with 50 member5s afflicted with IgAN or HSP and 150 other family members; 150 Caucasian patients with sporadic IgAN (no affected relatives) and 375 of their family members, 50 patients with HSP and 125 of their relatives, 50 African-American patients with IgAN and 200 family members, 50 patients with non-IgAN glomerulonephritis, and 200 Caucasians and 100 African-Americans as health controls. This proposal is based on novel findings generated in the laboratories of the participating investigators, with respect to genetic, biosynthetic, and metabolic studies of IgA molecules, immune complexes, and relevant receptors involved in IgA catabolism. The Program Project consists of three component research project and two core facilities: Project 1: Genetic Studies of IgA Nephropathy Project 2: Biosynthesis and Glycosylation of IgA1 Molecules in IgA Nephropathy Project 3: Immune Complexes and Mesangial Cells in IgA Nephropathy Core A: Clinical Resources and Biostatistics Core B: Administrative The results generated through extensive collaboration among the participating investigators are likely to provide information concerning the genetic and molecular defects characteristic of IgAN, identify mechanisms of the pathogenesis of this disease, and ultimately provide a basis to develop rational therapeutic approaches.

IgA肾病(IgAN)是世界上最常见的原发性肾小球肾炎。由于其经常出现的不良反应和缺乏特效治疗，IgAN是一个严重的医疗和经济问题。拟议计划项目的总体目标是通过对IgAN或过敏性紫癜(HSP)患者的综合研究来确定这种常见疾病的遗传和分子基础。HSP通常被认为是导致IgAN的疾病过程的系统性形式。我们将纳入20个多重家庭，其中50人患有IgAN或HSP及150名其他家庭成员，150名散发性IgAN患者(无亲属)及其375名家庭成员，50名HSP患者及其亲属，50名非洲裔IgAN患者及200名家庭成员，50名非IgAN肾小球肾炎患者，200名高加索人及100名非裔美国人作为健康对照。这一建议是基于参与研究人员的实验室中产生的关于参与IgA分解代谢的IgA分子、免疫复合体和相关受体的遗传、生物合成和代谢研究的新发现。该计划项目由三个组成部分的研究项目和两个核心设施组成：项目1：IgA肾病的遗传学研究项目2：IgA肾病中IgA1分子的生物合成和糖基化项目3：IgA肾病中的免疫复合物和系膜细胞核心A：临床资源和生物统计学核心B：行政管理通过参与研究人员的广泛合作产生的结果可能提供有关IgAN的遗传和分子缺陷特征的信息，确定这种疾病的发病机制，并最终为开发合理的治疗方法提供基础。