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IN VIVO IMAGING IN AUTOIMMUNE UVEITIS

IN VIVO IMAGING IN AUTOIMMUNE UVEITIS
自身免疫性葡萄膜炎的体内成像
批准号：
6747845
负责人：
HENRY Jerrold KAPLAN
金额：
$54.6万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-09-30 至 2005-09-29
来源：
https://reporter.nih.gov/project-details/6747845
关键词：
B lymphocyte T lymphocyte antigen presenting cell autoimmune disorder bioimaging /biomedical imaging cell adhesion cell migration chemical synthesis chemokine cytokine receptors disease /disorder model eye laboratory rat leukocyte activation /transformation method development natural killer cells positron emission tomography radiotracer receptor expression uveitis

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中文摘要
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英文摘要
Acute anterior uveitis (AAU), the most common form of intraocular inflammation in man, is an autoimmune disease of the eye. Experimental autoimmune anterior uveitis (EAAU) is a rodent model of AAU. It is produced in the Lewis rat by sensitization to melanin associated antigen (MAA) derived from bovine iris and ciliary body and is mediated by CD4+ T cells. The behavior and function of immune cells in vivo has been hampered by reliance on in vitro tissue culture systems, histologic analysis of tissues or the analysis of cell/factors from sacrificed animals. Recent advances in in vivo imaging techniques has allowed the development of scaled down positron emission tomography (PET) instrumentation with high-resolution and signal sensitivity for application in small animal model. We propose to combine our expertise in PET scanning and the production of positron emitting nucleotides in the Department of Radiology with our expertise in immunology in the Department of Ophthalmology and Visual Sciences to study the immunopathogenesis of EAAU. The specific aims of this proposal are: 1. Design, synthesis and evaluation of relevant pharmaceutical tools. 2. Effect of radionuclide labeled antibodies on immune cell function and binding of the antibodies to their target antigens. 3. Immune cell migration and localization in EAAU.
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