Translational Research in Systemic Vasculitis

描述（申请人提供）：全身性血管炎是一组血管炎性疾病。由于对这些疾病的病理生理学知识仍然不完整，它们的治疗是经验性的，有毒的，并且常常不能引起持久的缓解。约翰霍普金斯大学血管炎中心主任John Stone博士描述的这项转化研究项目的见解可能会导致评估血管炎患者的新方法。Stone博士为对转化研究感兴趣的初级研究人员提供了一个大型的血管炎患者数据库，为临床研究培训提供了优秀的机构资源，承诺的指导，在约翰霍普金斯大学内外建立了良好的合作关系，以及对职业发展至关重要的研究基础设施。作为该应用程序背景下的程序化研究目标，Stone博士将利用当前的资金和现有的合作来发展他在蛋白质组学方面的工作。他在这项工作中的合作研究者是美国国家癌症研究所/食品和药物管理局（NCI/FDA）临床蛋白质组学项目的合作者，Emanuel petroin博士和Lance Liotta博士。资金来自马里兰州关节炎研究联盟（MARRC）和美国食品和药物管理局孤儿产品办公室

DESCRIPTION (provided by applicant): Systemic vasculitis is a group of inflammatory disorders of blood vessels. Because knowledge of the pathophysiology of these conditions remains incomplete, their treatments are empiric, toxic, and often unsuccessful in inducing durable remissions. Insights derived from this translational research program described by Dr. John Stone, Director of the Johns Hopkins Vasculitis Center, may lead to novel methods of evaluating vasculitis patients. Dr. Stone's mentoring program for junior investigators interested in translational research provides access to a large database of well-characterized patients with vasculitis, outstanding institutional resources for clinical research training, committed mentoring, well-established collaborations within and outside of Johns Hopkins, and a research infrastructure that is essential to career development. As a programmatic research goal in the context of this application, Dr. Stone will employ current funding and existing collaborations to develop his work in proteomics. His co-investigators in this effort are collaborators at the National Cancer Institute/Food & Drug Administration (NCI/FDA) Clinical Proteomics Program, Dr. Emanuel Petricoin and Dr. Lance Liotta. Funding from the Maryland Arthritis Research Consortium (MARRC) and from the Food & Drug Administration's Office of Orphan Products Development will support these studies. The initial disease focus of this work will be Wegener's granulomatosis, using sera collected in the Wegener's Granulomatosis Etanercept Trial (A multicenter, NIAMS-funded trial in which Dr. Stone is the Principal Investigator). Other areas of research at the Vasculitis Center on which young investigators may choose to focus include: 1) the investigation of novel therapeutic approaches; 2) the role of microbial pathogens in the etiology of vasculitis; and, 3) molecular mechanisms of systemic vasculitis (under co-mentoring arrangements with colleagues whose expertise complements that of Dr. Stone), using patient samples and clinical data from the Vasculitis Center.