New Technologies in Electrophysiology Intervention

描述（由申请人提供）： Halperin博士研究生涯的重点一直是扩展基础和 将调查应用于以病人为中心的研究。他的作品曾 主要是在心肺复苏领域， 电生理学，在那里他继续应用科学为基础的技术 发展到临床医学。他首先研究了 血液在心肺复苏过程中移动。这项工作导致了 气动背心心肺复苏术的发展，它提供了高力的圆周 胸外按压临床前研究表明，充气背心心肺复苏术 与人工心肺复苏术相比，血液流动和存活率都得到了改善。 Halperin开发了一种临床气动背心CPR系统， 对于临床研究，获得了FDA对临床研究的批准，以及 在《新英格兰医学杂志》上发表了这一结果。 博士Halperin的兴趣从心肺复苏扩展到 包括电生理学，因为引起心脏病的心律失常 是电生理学家的主要兴趣。的主要限制 然而，研究患者心律失常的能力不足， 技术来准确地关联解剖和电信息。 解剖学是从X射线图像中衍生出来的，X射线图像是二维的， 解剖学上的模糊性另一个主要的限制是缺乏 能够在导管消融期间可视化心肌消融区域 程序. Halperin博士发明了一种方法， 来自磁共振成像（MRI）的信息， 测试和导管消融。临床前研究表明， 进行MRI引导的电生理研究和导管的可行性 Halperin博士正在将这项技术扩展到以患者为导向的 research. Halperin博士被授予生物工程研究合作伙伴关系 从NHLBI赠款追求这个项目，这是他目前的重点 research. Halperin医生？的持续应用科学为基础的 技术发展到临床医学，体现了他以病人为本的承诺 研究和他进行这项研究的能力。所有技术 已充分发展，使研究得以进行，但继续 可能会有改善。该奖项将帮助免费保护时间， 做这些研究，否则将用于执行标准的临床 职责通过提供50%的工资支持，该奖项将允许至少50%的 Halperin医生的时间被保护从标准的病人护理活动。 受保护的时间将使他有更多的时间追求以病人为导向的 这项建议概述的研究，并帮助培训年轻的临床 investigators.

DESCRIPTION (provided by applicant): The focus of Dr. Halperin's research career has been extending basic and applied investigation to patient-oriented research. His work has been primarily in the fields of cardiopulmonary resuscitation and electrophysiology, where he continues to apply scientifically-based technology development to clinical medicine. He first studied the mechanisms whereby blood moved during cardiopulmonary resuscitation. That work led to the development of pneumatic vest CPR, which provides high-force circumferential chest compressions. After pre-clinical studies showed that pneumatic vest CPR improved blood flow and survival over that obtained with manual CPR, Dr. Halperin developed a clinical pneumatic vest CPR system, developed protocols for clinical studies, obtained FDA approval for the clinical studies, and published the results in the New England Journal of Medicine. Dr. Halperin's interests broadened from cardiopulmonary resuscitation to include electrophysiology, given that the arrhythmias that cause cardiac arrest are a major interest of electrophysiologists. A major limitation in studying arrhythmias in patients, however, is the lack of ability of current technology to accurately correlate anatomical and electrical information. Anatomy is derived from x-ray images, which are two-dimensional and have substantial anatomic ambiguity. Another major limitation is the lack of ability to visualize ablated areas of myocardium during catheter ablation procedures. Dr. Halperin has invented ways of combining the anatomic information from magnetic resonance imaging (MRI), with electrophysiologic testing and catheter ablation. After pre-clinical studies demonstrated the feasibility of performing MRI-guided electrophysiologic studies and catheter ablation, Dr. Halperin is extending this technology to patient-oriented research. Dr. Halperin has been awarded a Bioengineering Research Partnership grant from NHLBI to pursue this project, which is the current focus of his research. Dr. Halperin?s continued application of scientifically-based technology development to clinical medicine shows his commitment to patient-oriented research and his ability to perform that research. All technology has been sufficiently developed to allow the studies to proceed, but continued improvements will likely occur. This award would help free protected time to do these studies that would otherwise be used for performing standard clinical duties. By providing 50% salary support, this award would allow at least 50% of Dr. Halperin's time to be protected from standard patient care activities. That protected time would allow him more time to pursue the patient-oriented studies outlined in this proposal, and help train young clinical investigators.