Investigating the mode of actionand target proteins of novel herbicide leadsusing the Marchantia polymorphamodel system

利用地钱模型系统研究新型除草剂先导物的作用模式和靶蛋白

• 批准号: 2270022
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2270022
• 关键词: Investigating; mode; actionand; target; proteins

The application of herbicides to control populations of weeds in crops is common practice in modern agriculture. This process aims to increase yields by reducing losses caused by the presence of weeds, which compete with crops for resources such as light, water and nutrients. However, the extensive use of a limited range of herbicides over long periods of time threatens to reduce the efficacy of herbicide application. This is because many weed species have evolved resistance to the limited number of herbicides used by farmers. The reduction in the number of herbicide options for farmers has been exacerbated by no new herbicide mode of action being brought to market in the last 30 years. One way in which the herbicide resistance problem canbe combatted is by developing new herbicides with novel modes of action to which there is no resistance. Herbicide discovery rates are far lower than they once were, however, with the development of new methods of discovery, new compounds with herbicidal activity are beginning to be uncovered.The company,MoA Technology,has identified several compounds with herbicidal activity using a high-throughput in vivo method. This project aims to determine how some of these novel herbicides which are currently in development kill plants. This will be done using a variety of methods in the model land plant system Marchantia polymorpha. A detailed understanding of how these compounds affect plant growth, and in particular spore development in Marchantia, will increase the chances of MoA Technology bringing an effective commercial herbicide to market. Furthermore, a detailed analysis of how a selection of these lead compounds affect their target, and the function of this target in wild-type lines, will increase our ability to manage the development of resistance to these compounds if they are one day used in the field. Increasing the longevity of new herbicides will ensure the new found variety of herbicides available to farmers will be maintained, allowing efficient food production to feed a growing demand in the future.

施用除草剂来控制作物中的杂草种群是现代农业中的常见做法。这一过程旨在通过减少杂草造成的损失来增加产量，杂草与作物争夺光、水和养分等资源。然而，在长时间内广泛使用有限范围的除草剂有可能降低除草剂施用的功效。这是因为许多杂草物种已经进化出对农民使用的有限数量的除草剂的抗性。过去30年来，由于没有新的除草剂作用模式进入市场，农民的除草剂选择数量减少。解决除草剂耐药性问题的一种方法是开发具有新作用模式的新除草剂，这种除草剂不会产生耐药性。除草剂的发现率远低于以往，然而，随着新的发现方法的发展，具有除草活性的新化合物开始被发现。MoA Technology公司使用高通量体内方法鉴定了几种具有除草活性的化合物。该项目旨在确定目前正在开发的一些新型除草剂如何杀死植物。这将使用各种方法在模型陆地植物系统地钱多形。详细了解这些化合物如何影响植物生长，特别是地钱属的孢子发育，将增加MoA技术将有效的商业除草剂推向市场的机会。此外，对这些先导化合物的选择如何影响其靶点以及该靶点在野生型系中的功能进行详细分析，将提高我们管理这些化合物耐药性发展的能力，如果它们有一天在该领域使用的话。增加新除草剂的使用寿命将确保农民能够获得新发现的除草剂品种，从而使高效的粮食生产能够满足未来不断增长的需求。