CORE--MAGNETIC RESONANCE IMAGING

核心——磁共振成像

• 批准号: 6573863
• 负责人: JAMES R EWING
• 金额: $ 17.32万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6573863
• 关键词: biomedical facility; magnetic resonance imaging

This proposal is two separate Cores summed into one administrative unit, representing two research groups in Henry Ford Health Systems; the Neurology NMR laboratory, which will oversee the Magnetic Resonance Imaging (MRI) sections of the proposed Program Project, and the Radiology Image Analysis Laboratory, which will oversee the visualization and combination of MRI (and other) images. It is the focus of Neurology NMR, and its responsibility in this Core, to parameterize MRI data in animal models of cerebral ischemia, and in humans with acute and chronic stroke. Neurology NMR is charged with data acquisition and data processing to produce maps of such parameters as proton density, T1, T2, cerebral blood flow (CBF), the apparent diffusion coefficient of water (ADC/W), the apparent forward magnetization transfer rate, K(fa), etcetera, in order to construct physical and physiological models of cerebral tissue across the phases of cerebral ischemia. To this end, the practices and principles of the MRI image acquisition and data processing used in the various Projects of the Program Project Proposal are presented in this Core, Section A. It has been the focus of the Radiology Image Analysis Laboratory to combine MRI (and other image data) in humans and animal models. In large part, because of the signal-to-noise advantage gained, image intensities alone (e.g., a set of spin-echo images, rather than a T2 map) are input to the algorithms employed by this group. Given an identified pure tissue signal, it has been possible to employ image processing algorithms in the identification of regions of irreversible tissue damage versus borderline regions, versus undamaged regions, versus regions with partial-volume effects. These techniques particularly the Eigenimage and ISODATA filters, are valuable because they employ all the information in an image set and, with experience, they allow the non-invasive identification of different tissue types. The practices and principles of Image Processing used in the various Projects of this Program Project proposal are presented in this Core, Section B. Finally, it is the purpose of this core to apply the work of both groups to the MRI study of cerebral infarction in animals and humans, and to combine their work so that the results of the image processing approaches can be mapped across field strengths and species.

本提案是两个独立的核心合并为一个行政单位，代表亨利福特健康系统的两个研究小组;神经学NMR实验室，将监督拟议计划项目的磁共振成像（MRI）部分，放射学图像分析实验室，将监督MRI（和其他）图像的可视化和组合。神经学核磁共振的重点是对脑缺血动物模型以及急性和慢性中风患者的核磁共振数据进行参数化。神经学NMR负责数据采集和数据处理，以产生诸如质子密度、T1、T2、脑血流量（CBF）、水的表观扩散系数（ADC/W）、表观正向磁化传递速率K（fa）等参数的图，以便构建脑缺血各阶段的脑组织的物理和生理模型。为此，本核心部分A节介绍了计划项目提案各个项目中使用的MRI图像采集和数据处理的实践和原则。在人类和动物模型中结合联合收割机MRI（和其他图像数据）一直是放射学图像分析实验室的重点。在很大程度上，由于获得的信噪比优势，单独的图像强度（例如，一组自旋回波图像，而不是T2图）被输入到该组所采用的算法。给定所识别的纯组织信号，可以采用图像处理算法来识别不可逆组织损伤的区域与边界区域、与未损伤区域、与具有部分体积效应的区域。这些技术，特别是特征图像和ISODATA滤波器，是有价值的，因为它们采用图像集中的所有信息，并且根据经验，它们允许不同组织类型的非侵入性识别。本核心报告B部分介绍了本项目建议书中各个项目所使用的图像处理的实践和原理。最后，本核心的目的是将这两个小组的工作应用于动物和人类脑梗死的MRI研究，并将他们的工作联合收割机结合起来，以便图像处理方法的结果可以跨场强和物种进行映射。