CRYSTALLOGRAPHIC STUDIES OF IRON DEPENDENT REPRESSOR FROM M TUBERCULOSIS

腺嘌呤磷酸核糖基转移酶(Aprt)是一种嘌呤残留物。 催化核糖-5-磷酸转移至腺嘌呤的酶， 产生AMP和焦磷酸盐。尽管哺乳动物会合成嘌呤 从新开始，寄生原生动物必须从它们的宿主那里清除嘌呤。 癌细胞的快速分裂也严重依赖于嘌呤的挽救。 它们的嘌呤来源的途径。APRT是一种重要的使能酶 寄生虫和肿瘤细胞循环宿主嘌呤，为此 原因是，它是治疗癌症药物的一个有希望的靶点。 和寄生虫感染。

Adenine phosphoribosyltransferase (APRT) is a purine salvage enzyme that catalyzes the transfer of ribose-5-phosphate to adenine, creating AMP and pyrophosphate. Although mammals synthesize purines de novo, parasitic protozoa must scavenge purines from their host. Rapidly dividing cancer cells also rely heavily on the purine salvage pathway for their purine source. APRT is an important enzyme enabling parasites and tumor cells to recycle host purines, and for that reason, it is a promising target for drugs aimed at treating cancers and parasitic infections.