结核分枝杆菌铁依赖性抑制子的晶体学研究-猫眼课题宝

结核分枝杆菌铁依赖性抑制子的晶体学研究

批准号：

6658690

负责人：

EHMKE POHL

金额：

$14.32万

依托单位：

STANFORD UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2002

资助国家：

美国

项目状态：

已结题

起止时间：

2002-03-01 至 2003-02-28

来源：

https://reporter.nih.gov/project-details/6658690

关键词：

bacteria bioimaging /biomedical imaging biomaterials biomedical resource proteins radiography structural biology

中文摘要

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英文摘要

Adenine phosphoribosyltransferase (APRT) is a purine salvage enzyme that catalyzes the transfer of ribose-5-phosphate to adenine, creating AMP and pyrophosphate. Although mammals synthesize purines de novo, parasitic protozoa must scavenge purines from their host. Rapidly dividing cancer cells also rely heavily on the purine salvage pathway for their purine source. APRT is an important enzyme enabling parasites and tumor cells to recycle host purines, and for that reason, it is a promising target for drugs aimed at treating cancers and parasitic infections.

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