CRYSTALLOGRAPHIC STUDIES OF IRON DEPENDENT REPRESSOR FROM M TUBERCULOSIS

结核分枝杆菌铁依赖性抑制子的晶体学研究

• 批准号: 6658690
• 负责人: EHMKE POHL
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6658690
• 关键词: bacteria; bioimaging /biomedical imaging; biomaterials; biomedical resource; proteins; radiography; structural biology

Adenine phosphoribosyltransferase (APRT) is a purine salvage enzyme that catalyzes the transfer of ribose-5-phosphate to adenine, creating AMP and pyrophosphate. Although mammals synthesize purines de novo, parasitic protozoa must scavenge purines from their host. Rapidly dividing cancer cells also rely heavily on the purine salvage pathway for their purine source. APRT is an important enzyme enabling parasites and tumor cells to recycle host purines, and for that reason, it is a promising target for drugs aimed at treating cancers and parasitic infections.

腺嘌呤磷酸核糖转移酶（APRT）是一种嘌呤补救酶， 对核糖-5-磷酸转化为腺嘌呤进行催化的酶， 产生AMP和焦磷酸盐 虽然哺乳动物合成嘌呤 从头开始，寄生原生动物必须从它们的宿主身上吸收嘌呤。 快速分裂的癌细胞也严重依赖嘌呤补救 嘌呤来源的途径。 APRT是一种重要的酶 寄生虫和肿瘤细胞来回收宿主嘌呤， 因此，它是治疗癌症药物的一个有希望的靶点 和寄生虫感染。