CRYSTAL STRUCTURES OF IRON DEPENDENT REPRESSOR

铁依赖性阻遏物的晶体结构

• 批准号: 6119481
• 负责人: EHMKE POHL
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119481
• 关键词: biomaterials; genome

We anticipate crystallizing DtxR and IdeR in complex with different oligonucleotides and hope to test these crystals at the SSRL synchrotron. So far, we have been able to obtain crystals of DtxR in complex with a 21mer oligonucleotide that diffract to about 6 E resolution at the SSRL beam lines. It is anticipated that higher resolution will allow the design of novel compounds that cause stronger DNA-binding of the repressor to DNA. The ultimate goal of our studies is the design of novel drugs against M. tuberculosis.

我们预计将DtxR和IDER结晶在与 不同的寡核苷酸，并希望在SSRL测试这些晶体 同步加速器。到目前为止，我们已经获得了DtxR的晶体 含有21聚体寡核苷酸的复合体，衍射量约为6E SSRL光束线的分辨率。预计更高的 解决方案将允许设计新的化合物，使 抑制子与DNA的结合更强。的最终目标是 我们的研究是设计抗结核分枝杆菌的新药。