CELL BIOLOGY

细胞生物学

• 批准号: 6563636
• 负责人: JOAN MASSAGUE
• 金额: $ 15.75万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-30 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6563636
• 关键词: biological signal transduction; carcinogenesis; cell biology; cell cycle; cell differentiation; cell proliferation; growth factor receptors; transcription factor; transforming growth factors

Description: The Cell Biology Program consists of 16 members whose major objective is to understand the signal mechanisms that control cell proliferation and differentiation and study the derangement of these mechanisms in cancer. The goal is to provide a framework for identification and neutralization of the alterations underlying cancerous growth. The Cell Biology Program underwent rapid growth just prior to the present grant period. The recruitment of six program members at that time significantly increased the size of the program. The current period has had as its objectives (1) to integrate and develop the careers of those newer members, (2) to recruit one new member of the program (Dr. Robert Fisher), and (3) to co-recruit the Director of the Human Genetics Program (Dr. Lucio Luzzatto). The decision to recruit Dr. Robert Fisher was made by the program Executive Committee, which consists of senior faculty. This committee meets bi-monthly to discuss the program and assess the research direction and productivity of junior faculty and evaluate them for promotion. The Executive Committee recruited Dr. Fisher for his expertise as a biochemist studying the cell cycle, an area of emphasis in this program. Program members receive a total of $1.6 million in direct costs from National Science Foundation (NSF), American Cancer Society (ACS), other NIH institutes, and the NCI. There are thirteen grants, including two Breast Cancer SPORE sub-projects, two grants from the NSF, three from the ACS, a sub-project on a U-19, and five R01-type grants, including a MERIT award to Dr. Massague. The mechanisms for promoting interaction includes a Chairman-sponsored, weekly, "Cell Regulation Work-in-Progress" seminar series. This involves approximately 30 of the Center?s basic and clinical investigators from various programs, including the entire faculty of this program. In addition, the Chairman meets with each faculty member yearly to assess progress. The program members use multiple core facilities in their research. Developmental funds were used to provide start-up funding for the laboratories of two investigators during the current cycle, both of whom are now funded.

描述：细胞生物学项目由16名成员组成，其专业 目的是了解控制细胞的信号机制 增殖和分化并研究这些的紊乱 癌症中的机制。目标是提供一个识别框架 和中和癌症生长的改变。 细胞生物学项目在目前之前经历了快速发展 授予期。当时招募六名节目成员 显着增加了程序的大小。本期已 其目标 (1) 整合和发展新人的职业生涯 成员，(2) 招募该计划的一名新成员（罗伯特·费舍尔博士），以及 （3）共同聘请人类遗传学项目主任（Lucio博士） 卢扎托）。招募罗伯特·费舍尔博士的决定是由该项目做出的 执行委员会由高级教师组成。本委员会开会 每双月讨论该计划并评估研究方向和 初级教师的生产力并评估他们的晋升。执行官 委员会聘请了费舍尔博士，因为他是一名生物化学家，研究 细胞周期是该计划的重点领域。 计划成员从 National 获得总计 160 万美元的直接费用 科学基金会 (NSF)、美国癌症协会 (ACS)、其他 NIH 机构、 和国家癌症研究所。有十三项资助，其中包括两项乳腺癌孢子资助 子项目，两项来自 NSF 的资助，三项来自 ACS 的资助，一个关于 U-19 和五项 R01 型补助金，包括授予 Massague 博士的优异奖。 促进互动的机制包括主席发起的、 每周一次“细胞调控正在进行中”研讨会系列。这涉及到 该中心大约 30 名来自不同国家的基础和临床研究人员 项目，包括该项目的全体教员。此外， 主席每年都会与每位教职员工会面，评估进展情况。这 项目成员在研究中使用多个核心设施。发育性 资金用于为两个实验室提供启动资金 本周期的调查人员，现在两人都得到了资助。