SELECTIVE ESTROGEN RECEPTOR MODULATOR EFFECTS ON SEROTONIN GENE EXPRESSION
SELECTIVE ESTROGEN RECEPTOR MODULATOR EFFECTS ON SEROTONIN GENE EXPRESSION
批准号:
6592352
负责人:
CYNTHIA Louise BETHEA
金额:
$11.11万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-05-01 至 2003-04-30
中文摘要
一项实验正在进行,以确定选择性雌激素是否
受体调节剂,称为雷洛昔芬和SERM 3,
在5-羟色胺神经元中的表达与天然的
雌激素. 对猴子进行绝育,然后用
媒介物、雌激素、雷洛昔芬或SERM3以5 mg/kg/天口服。 后
治疗后,将猴安乐死,并获得中脑用于
5-羟色胺再摄取转运蛋白基因表达的测定
和5HT1A自身受体基因。 Eli Lilly Pharmaceutical Co.
出版物
英文摘要
An experiment is underway to determine if the selective estrogen
receptor modulators, called raloxifen and SERM 3, alter gene
expression in serotonin neurons in the same manner as natural
estrogen. Monkeys are spayed and then treated for one month with
vehicle, estrogen, raloxifen, or SERM3 at 5 mg/kg/day orally. After
treatment, the monkeys are euthanized and the midbrain is obtained for
determination of expression of the serotonin reuptake transporter gene
and the 5HT1A autoreceptor gene. FUNDING Eli Lilly Pharmaceutical Co.
PUBLICATIONS None
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Postmenopausal Monkey Resource
-
批准号:9104295
-
项目类别:
-
资助金额:$25.63万
-
财政年份:2012
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Postmenopausal Monkey Resource
-
批准号:8337472
-
项目类别:
-
资助金额:$84.76万
-
财政年份:2012
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Postmenopausal Monkey Resource
-
批准号:8532068
-
项目类别:
-
资助金额:$48.85万
-
财政年份:2012
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Postmenopausal Monkey Resource
-
批准号:8705065
-
项目类别:
-
资助金额:$53.46万
-
财政年份:2012
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
OVARIAN STEROID REGULATION OF SEROTONIN NEURAL FUNCTION
-
批准号:8357731
-
项目类别:
-
资助金额:$5.82万
-
财政年份:2011
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
ROLE OF SEROTONIN IN MEDIATING STRESS-INDUCED INFERTILITY
-
批准号:8357841
-
项目类别:
-
资助金额:$5.82万
-
财政年份:2011
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
OVARIAN STEROID REGULATION OF SEROTONIN NEURAL FUNCTION
-
批准号:8357840
-
项目类别:
-
资助金额:$5.82万
-
财政年份:2011
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
IN VITRO MODEL DEVELOPMENT OF SEROTONIN NEURONS
-
批准号:8357741
-
项目类别:
-
资助金额:$3.63万
-
财政年份:2011
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
NOREPINEPHRINE IN STRESS-INDUCED AMENORRHEA OF MACAQUES
-
批准号:8357842
-
项目类别:
-
资助金额:$5.82万
-
财政年份:2011
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
TISSUE BANK
-
批准号:8125604
-
项目类别:
-
资助金额:$2.78万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
IN VITRO MODEL DEVELOPMENT OF SEROTONIN NEURONS
-
批准号:8173186
-
项目类别:
-
资助金额:$4.76万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Steroid Regulation of Serotonin in Males
-
批准号:8241173
-
项目类别:
-
资助金额:$32.37万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Steroid Regulation of Serotonin in Males
-
批准号:8403735
-
项目类别:
-
资助金额:$30.96万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Norepinephrine in Stress-Induced Amenorrhea of Macaques
-
批准号:8116585
-
项目类别:
-
资助金额:$25.2万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
OVARIAN STEROID REGULATION OF SEROTONIN NEURAL FUNCTION
-
批准号:8173177
-
项目类别:
-
资助金额:$7.61万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Steroid Regulation of Serotonin in Males
-
批准号:7889423
-
项目类别:
-
资助金额:$49.71万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Steroid Regulation of Serotonin in Males
-
批准号:8604749
-
项目类别:
-
资助金额:$32.14万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Norepinephrine in Stress-Induced Amenorrhea of Macaques
-
批准号:7771494
-
项目类别:
-
资助金额:$21.78万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
Steroid Regulation of Serotonin in Males
-
批准号:8079556
-
项目类别:
-
资助金额:$33.46万
-
财政年份:2010
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
IN VITRO MODEL DEVELOPMENT OF SEROTONIN NEURONS
-
批准号:7958417
-
项目类别:
-
资助金额:$8.03万
-
财政年份:2009
-
负责人:CYNTHIA Louise BETHEA
-
依托单位:
海外基金