TREATING ADDICTIONS OF SERIOUSLY MENTALLY ILL ADULTS

治疗患有严重精神疾病的成年人的成瘾行为

• 批准号: 6662117
• 负责人: Barbara E Havassy
• 金额: $ 17.92万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6662117
• 关键词: AIDS; HIV infections; adult human (21+); behavioral /social science research tag; clinical research; clinical trials; cocaine; comorbidity; depression; disease /disorder proneness /risk; drug abuse therapy; health care cost /financing; human subject; human therapy evaluation; longitudinal human study; outcomes research; patient care management; psychotherapy; quality of life; satisfaction; schizophrenia; smoking; smoking cessation; tobacco abuse

DESCRIPTION: (Applicant?s Abstract) The proposed randomized clinical trial is to test the effects of augmenting case managers? usual treatment of seriously mentally ill drug abusing patients by providing a distinctive intervention for drug abuse. The treatment, Behavioral Treatment for Substance Abuse in Schizophrenia--BTSAS (Bellack, Gearon, Everist, Alexander, 1998), is a six month intervention, provided in group format, designed to teach basic skills to facilitate reduction in drug use, to cope with stress, and to heighten awareness of negative consequences of substance abuse including increased risk of exposure to HIV. BTSAS (BT) is a promising, behavioral skills training treatment, developed under a NIDA treatment development grant DA09406 (Bellack) that has the advantage of a comprehensive and explicit manual to guide provision of treatment and training of therapists. The study will extend an established line of inquiry concerning effective treatments for drug-dependent seriously mentally ill adults. It is consistent with the focus of the TRC on treatment for complex drug-abusing patients, in clinical settings that have not typically provided specialized treatment for drug abuse and congruent with the TRC?s orientation towards cognitive behaviorally based interventions. The study will assess the effectiveness of adding BT to case management as usual and will test whether BT: (1) can be successfully exported to clinical case management settings; (2) can effect reduction in drug use and in the practice of AIDS risk behaviors; and (3) is associated with alterations of service utilization patterns that reflect a reduction in crisis treatment episodes and in treatment costs. Furthermore, the study will test whether BT: (4) is associated with improved quality of life; and (5) will have differential effects for participants who are cocaine-dependent. Primary hypotheses concern psychosocial and service utilization outcomes, and BT treatment processes. Secondary hypotheses concern status of cocaine-dependent participants relative to other study participants. This study is enhanced by Dr. Bellack?s consultation and by being integral to the scientific endeavors of the TRC. The collaborative style of the TRC will inform development of a smoking treatment intervention to be piloted in collaboration with Dr. Hall and the development of process measures with Dr. Sorensen to study case management for drug abusers. Core support for hypotheses testing and economic analyses will ensure the methods applied here will be among the most powerful.

描述：（申请人的摘要） 拟议的随机临床试验是为了测试增强的效果 案件经理？严重精神疾病吸毒者的常规治疗 通过对药物滥用提供独特的干预措施。治疗， 精神分裂症药物滥用的行为治疗 - BTSAS（Bellack， Gearon、Everist、Alexander，1998）是一项为期六个月的干预措施，提供于 小组形式，旨在教授基本技能以促进减少毒品 使用，应对压力，并提高对负面后果的认识 药物滥用，包括增加感染艾滋病毒的风险。 BTSAS (BT) 是 NIDA 下开发的有前途的行为技能训练治疗 治疗开发补助金 DA09406 (Bellack) 的优点是 指导治疗和培训提供的全面而明确的手册 治疗师。该研究将扩展既定的调查范围，涉及 对药物依赖的严重精神疾病成年人的有效治疗。这是 与真相与和解委员会对复杂药物滥用治疗的重点一致 患者，在通常不提供专门服务的临床环境中 药物滥用治疗并符合 TRC 的方向 基于认知行为的干预措施。该研究将评估 像往常一样将 BT 添加到案例管理中的有效性，并将测试是否 BT：（1）可以成功导出到临床病例管理设置； (2) 可以减少吸毒和艾滋病危险行为； (3) 与服务利用模式的改变相关 反映出危机治疗次数和治疗费用的减少。 此外，该研究将测试 BT：(4) 是否与改善 生活质量； (5) 将对参与者产生不同的影响 是可卡因依赖者。主要假设涉及心理社会和服务 利用结果和 BT 治疗过程。次要假设关注 可卡因依赖参与者相对于其他研究参与者的状况。 这项研究因贝拉克博士的咨询而得到加强，并成为 TRC 的科学努力。 TRC 的协作风格将 告知制定将在以下国家试点的吸烟治疗干预措施 与 Hall 博士合作并与 Dr. 一起制定流程措施。 索伦森研究吸毒者的案件管理。假设的核心支持 测试和经济分析将确保此处应用的方法将 其中最强大的。