DEVELOPMENTAL STUDIES ON TREATMENT OF COMPLEX PATIENTS

中心应用程序的这一发展部分延续了中心的传统，即支持培训和指导，以提高中心调查人员中经验较少的研究人员的技能，并进一步发展他们作为药物滥用研究人员的职业生涯。它为中心提供了一个统一的结构，高级调查人员可以继续成功地指导和发展更多初级同事，从而使中心和外地受益。我们建议推动高级研究培训，以促进初级研究人员和博士后学员之间强大的研究认同感的发展，并培养高级和初级研究人员之间的动态交流。这些科学活动是该中心的关键要素。这一部分的具体目标是：(1)为从事药物滥用治疗和服务研究的博士后实习生和初级调查人员管理一个竞争性的试点研究计划；(2)为博士后实习生和新的调查人员提供指导和教学机会；(3)支持TRC新调查人员的开发研究，从而获得R01申请。由派博士领导的试点研究计划将包括对博士后实习生的试点研究进行严格的审查和资助，这些研究将使R01的开发成为可能，并有望导致出版手稿。每个项目年度将资助两项先导研究，每项研究的最高资助为10,000美元。先进的培训还将反映在一个先进的方法研讨会上，该研讨会由国际和平协会和国际和平中心霍尔博士领导。研讨会旨在巩固经验较少的研究人员的技能和研究经验，重点是设计具有科学完整性和内部和外部有效性的严谨研究。在这一构成部分的主持下，总共将启动四项发展研究提案；其中两项在中心资助期的前半期进行，两项在下半年进行。提案将符合与科学卓越有关的特定标准，并将继续强调中心对复杂患者的药物滥用治疗。中心高级 哈瓦西博士、霍尔博士、索伦森博士、威尔谢博士和盖迪什博士将为准备这些研究的调查人员提供咨询。研究摘要将被审查，最有希望的将被邀请提交一份发展研究的提案。将审查这些项目的科学价值，一旦获得批准，将提交给NIDA中心的项目官员批准。

This developmental component of the Center application continues the Center tradition of supporting training and mentoring to enhance the skills of less experienced researchers among Center investigators and to further their careers as drug abuse researchers. It provides a unifying structure around with Center senior investigators can continue their successful mentoring and development of more junior colleagues, thus benefiting the Center and the field. We propose to promote advanced research training to foster development of strong research identities among junior investigators and post-doctoral trainees, and to cultivate a dynamic interchange between senior and junior investigators. These scientific activities are crucial elements of the Center. Specific aims of this component are: (1) administer a competitive pilot study program for post-doctoral trainees and junior investigators who are working in drug abuse treatment and services research; (2) provide direction and didactic opportunities for advanced research training for post-doctoral trainees and newer investigators; and (3) support developmental research of TRC new investigators leading to R01 applications. The pilot studies program, lead by the component PI, Dr. Havassy, will consist of stringent review and funding of pilot research of post-doctoral trainees, research that will enable development of a R01 and that has the promise of resulting in a published manuscript. Two pilot studies will be funded each project year and the maximum funding is $10,000 per study. The advanced training will also be reflected in an advanced methods seminar, lead by the PI and the Center PI, Dr. Hall. The seminar is designed to consolidate skills and research experience of less experienced investigators with a focus on design of rigorous studies with scientific integrity and with internal and external validity. Under the auspices of this component, a total of four developmental research proposals will be initiated; two conducted in the first half of the Center funding period and two in the latter half. Proposals will meet specified criteria having to do with scientific excellence and will continue the emphasis of the Center on drug abuse treatment for complex patients. Center senior investigators, Drs. Havassy, Hall, Sorensen, Welsher and Guydish, will provide consultation to the investigators preparing these studies. Study abstracts will be reviewed and the most promising will be invited to submit a proposal for a developmental study. These will be reviewed for scientific merit and once approved for funding will be sent to NIDA Centers project officer for approval.