DEVELOPMENTAL STUDIES ON TREATMENT OF COMPLEX PATIENTS

本中心申请的这一发展部分延续了本中心支持培训和指导的传统，以提高本中心调查人员中经验不足的研究人员的技能，并进一步发展他们作为药物滥用研究人员的职业生涯。它提供了一个统一的结构，使中心的高级研究人员能够继续成功地指导和发展更多的初级同事，从而使中心和领域受益。我们建议促进高级研究培训，培养初级研究者和博士后研究人员强烈的研究身份，并培养高级和初级研究者之间的动态交流。这些科学活动是中心的重要组成部分。这一组成部分的具体目标是：(1)为从事药物滥用治疗和服务研究的博士后受训人员和初级调查人员管理一项竞争性试点研究方案；(2)为博士后研修生和新研究者提供进阶科研培训的指导和教学机会；(3)支持TRC新研究者的开发研究，以实现R01应用。试点研究计划由组成PI的哈瓦西博士领导，将包括对博士后实习生的试点研究进行严格审查和资助，这些研究将使R01的开发成为可能，并有望发表手稿。每个项目每年将资助两项试点研究，每项研究的最高资助为10,000美元。高级培训也将反映在由PI和中心PI Hall博士领导的高级方法研讨会上。该研讨会旨在巩固经验不足的研究人员的技能和研究经验，重点是设计具有科学完整性和内部和外部有效性的严谨研究。在这一组成部分的主持下，将发起共四项发展研究建议；两项在中心资助期的前半期进行，两项在后半期进行。提案将符合与卓越科学有关的特定标准，并将继续强调该中心对复杂病人的药物滥用治疗。中心高级

This developmental component of the Center application continues the Center tradition of supporting training and mentoring to enhance the skills of less experienced researchers among Center investigators and to further their careers as drug abuse researchers. It provides a unifying structure around with Center senior investigators can continue their successful mentoring and development of more junior colleagues, thus benefiting the Center and the field. We propose to promote advanced research training to foster development of strong research identities among junior investigators and post-doctoral trainees, and to cultivate a dynamic interchange between senior and junior investigators. These scientific activities are crucial elements of the Center. Specific aims of this component are: (1) administer a competitive pilot study program for post-doctoral trainees and junior investigators who are working in drug abuse treatment and services research; (2) provide direction and didactic opportunities for advanced research training for post-doctoral trainees and newer investigators; and (3) support developmental research of TRC new investigators leading to R01 applications. The pilot studies program, lead by the component PI, Dr. Havassy, will consist of stringent review and funding of pilot research of post-doctoral trainees, research that will enable development of a R01 and that has the promise of resulting in a published manuscript. Two pilot studies will be funded each project year and the maximum funding is $10,000 per study. The advanced training will also be reflected in an advanced methods seminar, lead by the PI and the Center PI, Dr. Hall. The seminar is designed to consolidate skills and research experience of less experienced investigators with a focus on design of rigorous studies with scientific integrity and with internal and external validity. Under the auspices of this component, a total of four developmental research proposals will be initiated; two conducted in the first half of the Center funding period and two in the latter half. Proposals will meet specified criteria having to do with scientific excellence and will continue the emphasis of the Center on drug abuse treatment for complex patients. Center senior investigators, Drs. Havassy, Hall, Sorensen, Welsher and Guydish, will provide consultation to the investigators preparing these studies. Study abstracts will be reviewed and the most promising will be invited to submit a proposal for a developmental study. These will be reviewed for scientific merit and once approved for funding will be sent to NIDA Centers project officer for approval.