PILOT--DEVELOPMENTAL RESEARCH PROGRAM

SPORE前列腺癌发展研究计划的总体目标是为前列腺癌中有前途的试点转化提供初始资金。该计划将强调对转化研究项目的支持，这些项目可以产生可临床验证的假设，这将有助于我们降低前列腺癌的发病率和死亡率，或改善前列腺癌患者的生活质量。SPORE行政核心将向所有机构研究人员（包括SPORE职业发展计划的参与者）征集不超过5页的创新转化研究提案。行政核心将帮助提交提案的研究人员制定翻译的具体目标和研究计划，因为这些研究人员中的许多人在这一领域没有专业知识。因此，这一过程将是一项重大的教育活动，并将进一步刺激创新的翻译具体目标和研究计划的发展，因为这些研究人员中有许多人在这一领域没有专业知识。因此，这一过程将是一项重大的教育活动，并将进一步促进创新的翻译研究概念的发展。执行委员会将采用客观标准对相互竞争的提案进行筛选。然后，选定提案的研究者将按照NIH R01的模式准备一份10页的提案。然后，将采用客观标准将这些建议转交给外部科学咨询委员会成员。然后，选定提案的研究者将按照NIH R01的模式准备一份10页的提案。然后，选定提案的研究者将按照NIH R01的模式准备一份10页的提案。然后，这些建议将转交外部科学咨询委员会成员，以确定优先次序。这些项目将获得一年的资助，并可再延长一年。作为我们不断努力扩大MDACC研究的一部分。在全机构范围内公布和征求试点项目。在提交的18个项目中，有7个被认为是纯粹的基础项目，尽管有价值，但与SPORE的翻译重点不一致。其余11名调查员分别作了介绍。此外，每位研究者还提交了一份结构化摘要，概述了提案、其潜在影响以及支持其可行性的初步数据。在这11个项目中，有6个被认为值得进行试点供资。这里提出的六个有价值的建议说明了选择候选项目的过程是成功的。

The overall aim of the SPORE Developmental Research Program in Prostate Cancer is to provide initial funding for promising pilot translational in prostate cancer. The program will emphasize the support of translational research projects that can generate clinically testable hypotheses that will help us reduce the incidence and mortality of prostate cancer or improve the quality of life of prostate cancer patients. Proposals of no more than 5 pages for innovative translational research will be solicited by the SPORE Administrative Core from all institutional investigators, including participants in the SPORE Career Development Program. The Administrative Core will help the investigators submitted proposals formulate translational specific aims and research plans, as many of these investigators will not have expertise in this area.. The process will therefore be a major educational activity and will further stimulate the development of innovative translational specific aims and research plans, as many of these investigators will not have expertise in this area. The process will therefore be a major educational activity and will further stimulate the development of innovative translational research concepts. Competing proposals will be screened by the Executive Committee by using objective criteria. Investigators of selected proposals will then prepare a 10-page proposal modeled after an NIH R01. The proposals will be then forwarded to members of the External Scientific Advisory Committee by using objective criteria. Investigators of selected proposals will then prepare a 10-page proposal modeled after a NIH R01. Investigators of selected proposals will then prepare a 10- page proposal modeled after an NIH R01. The proposals will be then forwarded to members of the External Scientific Advisory Committee for prioritization. The projects will be funded for 1 year and will be renewable for an additional year. As part of our continuing efforts to expand research at MDACC. An institution wide announcement and solicitation for pilot projects was made. Of 18 projects submitted, seven were considered to be purely basic and, although meritorious, not consistent with the translational focus of the SPORE. Presentations were made by each of the remaining 11 investigators. In addition, each investigator submitted a structured abstract outlining the proposals, its potential impac5t, and the preliminary data to support its feasibility. Of the 11 projects, six were judged to be worthy of pilot funding. The six worthy proposals presented here illustrate the success of the process in selecting candidate projects.