University of Texas SPORE in Prostate Cancer

德克萨斯大学医学博士安德森的这一目标是在前列腺癌中以一种有意义的方式消除前列腺作为一种健康风险。SPORE将通过聚集致力于前列腺癌转化研究的优秀临床和基础科学家来实现这一目标。MD安德森是一个独特的中心，它为多学科的基础应用和临床研究提供了一个支持性的环境。MD安德森癌症中心已将消除前列腺癌作为一种健康风险列为优先事项。为了实现这一目标，该中心建立了前列腺癌研究项目（PCRP），其目的是支持跨传统行政边界的MD安德森前列腺癌研究。PCRP已经有可能招募新的研究人员到该机构，并支持现有教师在前列腺癌的研究。通过支持试点项目、加强研究基础设施和支持预防前列腺癌的新举措，后一个目标已经实现。由于PCRP的支持，我们已经召集了研究人员，准备利用最近在前列腺癌中进行的许多基础和临床观察。该SPORE的资助将加强将基本观察转化为临床的努力，并了解临床观察的基本基础。该方案由一名高级基础和临床研究员领导，有五个项目，提供两个职业发展奖和四个试点项目。三个核心（行政，病理学，生物统计学）由在所选领域有成就记录的研究人员领导。核心小组的各个组成部分将提供支持，确保项目的完成。这五个项目是在临床和基础科学家的密切合作下开发的，重点是针对晚期前列腺癌的补充研究。该计划的基础包括五个项目：1）人类前列腺癌的生物学和治疗2）靶向前列腺骨转移3）前列腺癌患者细胞凋亡的治疗调节4）探索前列腺癌诊断和治疗靶向血管的分子多样性和5）前列腺癌进展的流行病学，分子和临床决定因素。MD安德森前列腺癌SPORE将促进与现有前列腺癌SPORE成员的新的和进一步的合作，以实现开发有效的策略来预防、检测和治疗前列腺癌的共同目标。

The goal of this University of Texas MD Anderson SPORE in prostate cancer in a meaningful way to the elimination of prostate as a health risk. The SPORE will achieve this by assembling talented clinical and fundamental scientists who are dedicated to translational research in prostate cancer. The MD Anderson is a unique Center, which provides a supportive environment for multi-disciplinary basic applied and clinical research. The elimination of prostate cancer as a health risk has been made a priority of the MD Anderson Cancer Center. To achieve this goal the Center has established the Prostate Cancer Research Project (PCRP) whose purposes to support research in prostate cancer at the MD Anderson across traditional administrative boundaries. The PCRP has made it possible to recruit new investigators to the institution and support the research of existing faculty in prostate cancer. This later aim has been achieved by supporting pilot projects, strengthening the research infrastructure, and supporting new initiatives in prevention of prostate cancer. As a result of PCRP support we have assembled investigators poised to exploit the many basic and clinical observations recently made in prostate cancer. The funding of this SPORE will enhance the efforts to translate basic observations into the clinic and understand the fundamental basis of clinical observations. The SPORE is led by a senior basic and clinical investigator and has five projects with provision for two career development awards and four pilots' projects. The three Cores' (administrative, pathology, biostatistics) are led by investigators with a track record of accomplishment in their chosen field. The individual CORE elements will provide the support that will assure the completion of the projects. The five projects have been developed in a close collaboration between clinical and fundamental scientists and focus on complimentary studies targeting advanced prostate cancer. The five projects that comprise the foundation of this proposal are: 1) Biology and therapy of human prostate cancer 2) Targeting prostate bone metastasis 3) Therapeutic modulation of apoptosis in prostate cancer patients 4) Exploring the molecular diversity of blood vessels for diagnostic and therapeutic targeting of prostate cancer and 5) Epidemiologic, molecular, and clinical determinants of prostate of prostate cancer progression. The MD Anderson SPORE will promote new and further the existing collaborations with members of the established prostate cancer SPORE's to achieve the common purpose of developing effective strategies to prevent detect and treat prostate cancer.