TRAINING: HEMATOLOGY, IMMUNOLOYG & STEM CELL BIOLOGY

(改编自申请人的摘要)这是一项建立 分子和细胞跨学科博士后培训计划 生物学，重点是血液学、免疫学和干细胞生物学 儿童医院奥克兰研究所(CHORI)。支持六个 这项资助每年都需要博士后研究员。实习生与 博士、医学博士/博士或医学博士学位都有资格参加该项目。实习生是 预计在细胞或分子生物学方面都有很强的背景， 遗传学、生物化学或生理学，才能被录取。 该项目强调在有经验的、 美国国立卫生研究院支持调查人员。由CHORI的导师组成的委员会将 选择候选人，并将确定他们将在哪个实验室 工作。每个受训者将开发一个研究假设，并写一份迷你 该提案将由本申请的主计长和副主计长审查。 学员将参加核心课程活动，并将在 每月讨论个别项目的进展情况并提供数据。 此外，受训人员还将参加每周一次的实验室会议。 由他们的导师，由P.I.和Co-P.I.指导的周刊俱乐部，以及 在CHORI举办的每周系列研讨会。受训人员将被期望 在全国会议上展示他们的研究成果。所有受训人员将被要求 在第二次或第二次会议期间准备一份寻求校外资金的研究提案 第三年的训练。 导师将协助准备这份申请。 该计划中的研究培训机会将包括：1)学习方法 开展以镰状细胞性贫血为重点的血液学临床研究 2)红细胞膜结构和功能的研究 利用分子、生化和生物物理技术，3)研究 免疫学发展，对多肽模拟物的免疫反应，分子 人类白细胞抗原系统及其与免疫缺陷的关系分析 血红蛋白病患者，4)铁代谢和分子生物学研究 铁蛋白的调节，5)脂质介导的信号转导研究 细胞生物学，6)研究细胞的遗传操作，特别是 使用腺相关病毒载体的造血干细胞和研究 造血干细胞生物学，重点是脐带血造血 干细胞。这项由美国国立卫生研究院资助的医学博士和 博士将为实习生提供丰富的经验，并将满足需求 对于对血液学研究特别感兴趣的年轻科学家来说， 适用于血红蛋白疾病领域。 1

(Adapted from applicant's abstract) This is a proposal to establish an interdisciplinary postdoctoral training program in molecular and cellular biology with a focus on hematology, immunology and stem cell biology at the Children's Hospital Oakland Research Institute (CHORI). Support for six postdoctoral fellows is requested in each year of this grant. Trainees with Ph.D., M.D./Ph.D. or M.D. degrees are eligible for the program. Trainees are expected to have a strong background in either cell or molecular biology, genetic, biochemistry or physiology in order to be accepted into the program. The program emphasis hands-on bench work in the laboratory of an experienced, NIH supported investigator. A committee composed of the mentors at CHORI will select the candidates and will determine the laboratory in which they will work. Each trainee will develop a research hypothesis and write a mini proposal which will be reviewed by the P.I. and Co-PI of this application. Trainees will participate in core curriculum activities and will meet on a monthly basis to discuss progress on individual projects and to present data. In addition, trainees will participate in weekly laboratory meetings directed by their mentors, weekly journal clubs directed by the P.I. and Co-P.I., and weekly seminar series conducted at CHORI. Trainees will be expected to present their research at national meetings. All trainees will be expected to prepare a research proposal seeking extramural funding during their second or third year of training. The mentor will assist in preparing this application. Research training opportunities in this program will include: 1) Learning how to conduct clinical research in hematology with a focus on sickle cell anemia and thalassemia, 2) Studying red cell membrane structure and function studies using molecular, biochemical and biophysical techniques, 3) studying immunologic development, immune response to peptide mimetics, molecular analysis of the HLA system and their relationship to immune defects in patients with hemoglobinopathies, 4) Studies in iron metabolism and molecular regulation of ferritin, 5) studies of lipid mediated signal transduction in cell biology, 6) studies of genetic manipulation of cells, particularly hematopoietic stem cells, using adeno-associated viral vectors, and 7) studies of hematopoietic stem cell biology, with a focus on cord blood hematopoietic stem cells. This spectrum of research conducted by NIH funded M.D.s and Ph.D.s will provide a rich experience for trainees and will address the need for young scientists with a particular interest in hematology research that applies to the field of hemoglobinopathies. 1