Integrated functional imaging of the human brain

描述(申请人提供)：这是一份设立 生物工程研究伙伴关系(BRP)将开发和整合新的 全面绘制人脑功能图谱的技术。这些遗嘱 被用来研究大脑和意志中的功能连接网络 为正常神经基础和神经基础的系统分析提供信息 不正常的行为。它们将被应用于研究儿童的发展和 婴儿以及各种精神疾病的神经生物学基础， 发育和神经紊乱。BRP将开发非侵入性 工具、技术和算法来获取和组合 从先进的高场磁共振成像中获得的信息 (核磁共振)4特斯拉，近红外光学成像，电生理(包括 诱发反应)、跨磁刺激(TMS)和计算机数据分析 和图像处理。它将开发和验证新的表演手段 功能成像研究和记录认知和生理 在4T成像磁体的环境中的响应，以及 结合所涉及的各种互补技术的信息。这个 合作伙伴关系将把耶鲁大学内的6个核心实验室聚集在一起， 主办机构，还将密切涉及8家合作企业 合作伙伴以及来自其他8所大学的调查人员(Vanderbilt， 哥伦比亚大学和纽约大学，北卡罗来纳大学，康涅狄格州大学，俄勒冈健康科学中心， 南卡罗来纳州医学院和布朗克斯退伍军人医院)。业务流程再造计划将 包括物理学家、工程师、计算机科学家、神经科学家、 心理学家、精神病学家、儿科医生和放射科医生。在第一年 先进的功能成像方法将在4T实施，并且 ERP和NW所需的设备将进行改装，以用于磁铁。类似 这些模式、TMS和心理物理技术的发展将 持续到第二年和第三年。BRP的头三年将重点放在 用于归纳和评估的新技术的开发和验证 大脑对刺激的反应激活，而4岁和5岁会更专注 关于不同手段获取的数据集成的开发方法 以及在具体应用中对它们的分析和解释。这个 建立一个BRP将是一种理想的联合机制 脑功能研究的不同方法，以及 各种方法将为神经科学研究提供有价值的新资源 其能力将远远超过单独组件的总和。

DESCRIPTION (provided by applicant): This is an application to establish a Bioengineering Research Partnership (BRP) to develop and integrate new technologies for the comprehensive mapping of human brain function. These will be used to study functionally connected networks within the brain and will provide the information for systems analyses of the neural bases of normal and abnormal behaviors. They will be applied to study development in children and infants, as well as the neurobiological basis of various psychiatric, developmental and neurological disorders. The BRP would develop non-invasive instrumentation, techniques and algorithms to acquire and combine the information obtainable from advanced high field magnetic resonance imaging (MRI) at 4 Tesla, near infra-red optical imaging, electrophysiology (including evoked responses), trans-magnetic stimulation (TMS), and computer data analysis and image processing. It would develop and validate novel means of performing functional imaging studies and of recording cognitive and physiological responses within the environment of a 4T imaging magnet, as well as methods to combine the information from the various complementary techniques involved. The partnership would bring together 6 core laboratories within Yale University, the host institution, and would also closely involve 8 collaborating corporate partners as well as investigators from 8 other universities (Vanderbilt, Columbia and New York Universities, UNC, UConn, Oregon Health Sciences Center, Medical College of South Carolina, and the Bronx VA Hospital). The BRP will include physicists, engineers, computer scientists, neuroscientists, psychologists, psychiatrists, pediatricians and radiologists. During Year 1 advanced functional imaging methods will be implemented at 4T, and the equipment needed for ERP and NW will be modified for use in the magnet. Similar developments of these modalities, of TMS and psychophysical techniques, will continue through years 2 and 3. The first three years of the BRP would focus on the development and validation of novel techniques for inducing and assessing brain activation in response to stimuli, while years 4 and 5 would focus more on developing methods for the integration of data obtainable by different means and for their analysis and interpretation in specific applications. The establishment of a BRP would be an ideal mechanism for bringing together different approaches to the study of brain function, and the integration of the various methods will provide a valuable new resource for neuroscience research whose capabilities will far exceed the sum of the separate components.