Acquisition of a 9.4T Small Animal MRI/MRS System

购置9.4T小动物MRI/MRS系统

• 批准号: 6580570
• 负责人: JOHN C GORE
• 金额: $ 50万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580570
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; magnetic resonance imaging

DESCRIPTION (provided by applicant): This application from Vanderbilt University seeks partial funding for the acquisition of a state-of-the-art, high field (9.4T) Magnetic Resonance Imaging/Spectroscopy system that will be used to extend and improve various research programs involving small animals. This system is essential for several current NIH-funded projects including studies of tumor biology, neural function and development, diabetes, alcoholism and transgenic mice. It is also essential for several projects that involve fundamental studies related to the further development and application of MRI methods in medicine. The proposed facility will provide a major new capability for in vivo imaging and spectroscopy and thereby will permit current NIH-funded investigators to undertake studies which are essential for their projects but which are currently unable to be performed without this instrument. Several previous studies have been obtained using an existing and antiquated 4.7T system that has numerous technical limitations and which is not able to provide the quality of information needed for these projects. The new, higher field instrument will acquire images and spectra that have inherently higher signal to noise ratios, greater spatial and spectral resolution, and images, which are more sensitive to some contrast mechanisms. The proposed system will have a much better shim and gradient system and associated hardware, and will be based around a modern console and spectrometer capable of a wider array of modern experiments. These new capabilities will include fast and 3D imaging that is important for a variety of experiments, improved diffusion weighted imaging, and broadband multi-nuclear (H-1, P-31 and C-13) in vivo MR spectroscopy for studies of metabolism. The system will be an integral part of a new Center dedicated to research imaging and will be supported by a large and experienced group of physicists, engineers and computer scientists, along with a well trained and qualified group of support staff, including electronic engineers and animal technologists. These technical experts will take responsibility for assisting users in experimental design, data acquisition and data analysis. The proposed instrument will be a multi-user facility, supervised by a director and a core staff, developed and managed via an operating committee, and with oversight by an advisory committee charged with the responsibility of assuring appropriate access to NIH funded investigators. The acquisition of the proposed instrument will significantly increase the number and quality of investigations using small animal MRI and MRS and in turn will help Vanderbilt University meet its commitment to enhancing bench-to-bedside research in the areas of basic cancer biology and cancer therapy, neuroscience, structural biology and genetics.

描述（由申请人提供）： 范德比尔特大学的这份申请寻求部分资金，用于购买最先进的高场 (9.4T) 磁共振成像/光谱系统，该系统将用于扩展和改进涉及小动物的各种研究项目。该系统对于当前 NIH 资助的几个项目至关重要，包括肿瘤生物学、神经功能和发育、糖尿病、酗酒和转基因小鼠的研究。对于涉及与 MRI 方法在医学中的进一步开发和应用相关的基础研究的几个项目来说，它也是至关重要的。拟议的设施将为体内成像和光谱学提供重要的新功能，从而使目前由 NIH 资助的研究人员能够进行对其项目至关重要但目前如果没有该仪器就无法进行的研究。之前的几项研究是使用现有且过时的 4.7T 系统进行的，该系统具有许多技术限制，并且无法提供这些项目所需的高质量信息。新的更高场仪器将采集具有更高信噪比、更高空间和光谱分辨率的图像和光谱，以及对某些对比机制更敏感的图像。拟议的系统将拥有更好的匀场和梯度系统以及相关硬件，并将基于能够进行更广泛的现代实验的现代控制台和光谱仪。这些新功能将包括对各种实验非常重要的快速 3D 成像、改进的扩散加权成像以及用于代谢研究的宽带多核（H-1、P-31 和 C-13）体内 MR 光谱。该系统将成为致力于研究成像的新中心的组成部分，并将得到大批经验丰富的物理学家、工程师和计算机科学家以及训练有素、合格的支持人员（包括电子工程师和动物技术专家）团队的支持。这些技术专家将负责协助用户进行实验设计、数据采集和数据分析。拟议的工具将是一个多用户设施，由一名主任和一名核心工作人员监督，通过运营委员会开发和管理，并由负责确保适当接触 NIH 资助的研究人员的咨询委员会监督。收购拟议的仪器将显着增加使用小动物 MRI 和 MRS 进行的研究的数量和质量，反过来将有助于范德比尔特大学履行其加强基础癌症生物学和癌症治疗、神经科学、结构生物学和遗传学领域的实验室到临床研究的承诺。