Integrated functional imaging of the human brain

描述（由申请人提供）：这是一份建立 生物工程研究伙伴关系（BRP）开发和整合新的 全面绘制人类大脑功能的技术。这些将 用于研究大脑内的功能连接网络， 为正常人的神经基础的系统分析提供信息， 异常行为它们将被用于研究儿童的发展， 婴儿，以及各种精神疾病的神经生物学基础， 发育和神经系统疾病。BRP将开发非侵入性 仪器、技术和算法来获取和联合收割机， 可从高级高场磁共振成像获得的信息 (MRI)在4特斯拉，近红外光学成像，电生理学（包括 诱发反应）、跨磁刺激（TMS）和计算机数据分析 和图像处理。它将开发和验证新的表演手段， 功能成像研究和记录认知和生理 在4T成像磁体的环境内的响应，以及 联合收割机将所涉及的各种互补技术的信息结合起来。的 合作伙伴关系将汇集耶鲁大学的6个核心实验室， 主办机构，还将密切参与8家合作企业 合作伙伴以及来自其他8所大学的研究人员（范德比尔特， 哥伦比亚大学和纽约大学，康涅狄格大学，俄勒冈州健康科学中心， 南卡罗来纳州医学院和布朗克斯VA医院）。BRP将 包括物理学家，工程师，计算机科学家，神经科学家， 心理学家、精神病学家、儿科医生和放射科医生。第1年期间 先进的功能成像方法将在4T上实现， ERP和NW所需的设备将被修改用于磁铁。类似 TMS和心理物理学技术的发展， 持续到第二年和第三年。《两年期重建计划》的头三年将侧重于 开发和验证新技术， 大脑激活对刺激的反应，而第4年和第5年将更多地关注 关于制定方法，将通过不同手段获得的数据综合起来 以及在具体应用中对它们的分析和解释。的 建立一个BRP将是一个理想的机制， 研究大脑功能的不同方法，以及 各种方法将为神经科学研究提供宝贵的新资源 其能力将远远超过各个组成部分的总和。

DESCRIPTION (provided by applicant): This is an application to establish a Bioengineering Research Partnership (BRP) to develop and integrate new technologies for the comprehensive mapping of human brain function. These will be used to study functionally connected networks within the brain and will provide the information for systems analyses of the neural bases of normal and abnormal behaviors. They will be applied to study development in children and infants, as well as the neurobiological basis of various psychiatric, developmental and neurological disorders. The BRP would develop non-invasive instrumentation, techniques and algorithms to acquire and combine the information obtainable from advanced high field magnetic resonance imaging (MRI) at 4 Tesla, near infra-red optical imaging, electrophysiology (including evoked responses), trans-magnetic stimulation (TMS), and computer data analysis and image processing. It would develop and validate novel means of performing functional imaging studies and of recording cognitive and physiological responses within the environment of a 4T imaging magnet, as well as methods to combine the information from the various complementary techniques involved. The partnership would bring together 6 core laboratories within Yale University, the host institution, and would also closely involve 8 collaborating corporate partners as well as investigators from 8 other universities (Vanderbilt, Columbia and New York Universities, UNC, UConn, Oregon Health Sciences Center, Medical College of South Carolina, and the Bronx VA Hospital). The BRP will include physicists, engineers, computer scientists, neuroscientists, psychologists, psychiatrists, pediatricians and radiologists. During Year 1 advanced functional imaging methods will be implemented at 4T, and the equipment needed for ERP and NW will be modified for use in the magnet. Similar developments of these modalities, of TMS and psychophysical techniques, will continue through years 2 and 3. The first three years of the BRP would focus on the development and validation of novel techniques for inducing and assessing brain activation in response to stimuli, while years 4 and 5 would focus more on developing methods for the integration of data obtainable by different means and for their analysis and interpretation in specific applications. The establishment of a BRP would be an ideal mechanism for bringing together different approaches to the study of brain function, and the integration of the various methods will provide a valuable new resource for neuroscience research whose capabilities will far exceed the sum of the separate components.