Physical Limits of Quantitative SPECT

定量 SPECT 的物理极限

• 批准号: 6475397
• 负责人: MARIE FOLEY KIJEWSKI
• 金额: $ 49.08万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6475397
• 关键词: Alzheimer's disease; Parkinson's disease; aging; astrocytoma; attention deficit disorder; bioimaging /biomedical imaging; biomedical equipment development; brain disorder diagnosis; brain imaging /visualization /scanning; brain morphology; clinical biomedical equipment; clinical research; computer simulation; data collection methodology /evaluation; diagnosis design /evaluation; diagnosis quality /standard; human data; human subject; image processing; mathematics; method development; neuropathology; phantom model; radiotracer; single photon emission computed tomography

The long-term goal of this project is to develop quantitative imaging task based metrics and, using them, determine the fundamental limits on quantitative SPECT. In the previous project period, we focused on optimization of methods to correct for scatter, attenuation, and distance- dependent spatial resolution, as well as optimizing the acquisition strategy for imaging deep brain structures. In this renewal application, we turn our attention to the areas of simultaneous dual-isotope imaging, comparison of analytical and iterative image processing and reconstruction and on generalizing collimation advances, developed during the last project period for a dedicated brain system, to more commonly available dual-head systems. Our approaches include analysis, simulation, phantom experiments and patient studies. The analyses and simulation studies, although pertaining to prototypical estimation and classification tasks, will incorporate realistic anatomy and biological variability. We will continue the development of special-purpose collimators which sample the projections unequally in order to compensate for loss of information from central brain structures by attenuation. We will manufacture one such collimator, designed for a dedicated brain SPECT system during the last project period. We will design a similar collimator for a dual-head SPECT system, optimizing its performance for quantitative brain imaging tasks, relevant to Parkinson disease, using computer simulations of an anatomically realistic digital phantom. We will also determine the theoretical limits on activity estimation in simultaneous dual-energy imaging for both Tc/I and Tc/TI, and assess the value of dual-isotope imaging in clinical tasks related to glioblastoma and adult attention deficit hyperactivity disorder. We will compare analytical methods to correct for attenuation and distance dependent resolution to corrections incorporated into an iterative reconstruction algorithm in prototypical estimation tasks, as well as clinical tasks relevant to Alzheimer disease.

该项目的长期目标是开发基于定量成像任务的度量，并使用它们确定定量SPECT的基本限制。在之前的项目期间，我们专注于优化散射、衰减和距离相关空间分辨率的校正方法，以及优化脑深部结构成像的采集策略。在此更新应用中，我们将注意力转向同步双同位素成像，分析和迭代图像处理和重建的比较以及在上一个项目期间为专用脑系统开发的广义准直进展，以更常见的双头系统。我们的方法包括分析、模拟、模拟实验和患者研究。分析和模拟研究虽然属于原型估计和分类任务，但将纳入现实的解剖学和生物学变异性。我们将继续开发专用准直器，对投影进行不均匀采样，以补偿因衰减而导致的中央脑结构信息损失。我们将在最后一个项目期间制造一个这样的准直器，为专用的脑SPECT系统设计。我们将为双头SPECT系统设计一个类似的准直器，优化其在与帕金森病相关的定量脑成像任务中的性能，使用计算机模拟解剖学上真实的数字幻影。我们还将确定Tc/I和Tc/TI同时双能成像的活动估计的理论限制，并评估双同位素成像在胶质母细胞瘤和成人注意缺陷多动障碍相关的临床任务中的价值。我们将比较用于校正衰减和距离相关分辨率的分析方法与包含在原型估计任务中的迭代重建算法中的校正方法，以及与阿尔茨海默病相关的临床任务。