Objective Assessment of Suppression in Amblyopia

弱视抑制的客观评估

• 批准号: 6653071
• 负责人: Suzanne P McKee
• 金额: $ 17.06万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653071
• 关键词: amblyopia; behavioral /social science research tag; binocular vision; child (0-11); clinical research; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; electroencephalography; evoked potentials; human subject; neural information processing; noninvasive diagnosis; psychophysics; suppression; vision tests; visual perception; visual stimulus

DESCRIPTION (provided by applicant): We will design an objective test, based on the Visual Evoked Potential (VEP), to measure amblyopic suppression. Our basic tool is the VEP monocular response to periodic vernier onset/offset transitions in bar stimuli, and its suppression during dichoptic stimulation with matching contours. What is unique about this approach is that it identifies which eye is being suppressed as well as the visual acuity of each eye. Although we will develop and validate this test in adult subjects, our dichoptic visual display system has been specifically designed for ultimate use with infants and pre-verbal children. We also will use a new multi-channel recording system (Geodesic Sensor Net) to explore the neural basis for the differences between normal and abnormal binocular processing. About 4% of all children suffer from strabismus and/or anisometropia during early development. These abnormalities place an individual at risk for a variety of visual deficiencies. The most serious outcome is amblyopia in one eye. Amblyopia refers to a loss of visual acuity, without obvious organic cause, that cannot be corrected by wearing spectacles or contact lenses. Perhaps one third of strabismics and anisometropes suffer some loss in visual acuity. The proposed test could assist with the diagnosis of amblyopia in infancy, as well as in monitoring progress during treatment, thereby improving the chance of a favorable outcome.

描述（由申请人提供）：我们将设计一个基于视觉诱发电位（VEP）的客观测试来测量弱视抑制。我们的基本工具是 VEP 单眼响应条刺激中的周期性游标起始/偏移转换，以及在具有匹配轮廓的二视刺激期间的抑制。这种方法的独特之处在于，它可以识别哪只眼睛受到抑制以及每只眼睛的视力。尽管我们将在成人受试者中开发和验证该测试，但我们的二视视觉显示系统是专门为婴儿和语言前儿童的最终使用而设计的。我们还将使用新的多通道记录系统（测地传感器网络）来探索正常和异常双眼处理之间差异的神经基础。大约 4% 的儿童在早期发育期间患有斜视和/或屈光参差。这些异常使人面临各种视觉缺陷的风险。最严重的后果是一只眼睛弱视。弱视是指没有明显器质性原因，无法通过佩戴框架眼镜或隐形眼镜矫正的视力丧失。也许三分之一的斜视和屈光参差者的视力会受到一定程度的损失。拟议的测试可以帮助诊断婴儿期弱视，以及监测治疗过程中的进展，从而提高获得良好结果的机会。