COOPERATIVE AMBLYOPIA CLASSIFICATION STUDY

合作性弱视分类研究

• 批准号: 3559611
• 负责人: Suzanne P McKee
• 金额: $ 24.53万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3559611
• 关键词: adolescence (12-20); amblyopia; computer assisted diagnosis; cooperative study; disease /disorder classification; eye disorder diagnosis; human subject; middle childhood (6-11); psychophysics; young adult human (21-34)

This application is a participating center application for the first phase of the Cooperative Amblyopia Classification Study, a multi- center, planned, protocol based project to examine the existing clinical classification of amblyopia and compare it with a classification derived from the performance of the amblyopic eye on a set of specific psycho-physical tests. The data that emerge will be analyzed: - To determine a set of visual behaviors that distinguish amblyopic from normal eyes. - To determine clusters of visual behaviors that define different types of amblyopia. - To determine the correlation between types derived from psychophysical and oculomotor measures and clinical measures collected on the same patients. The statistical techniques of cluster analysis will be used on the measured clinical and psychophysical variables to examine the null hypothesis that the cluster of psychophysical measures can be predicted from the clinical classification and vice versa. The population studied will be amblyopic subjects, control subjects with clinical conditions usually associated with amblyopia but without the amblyopia and normal subjects. Ages range from 8 to 35 years. Full details of the project are contained in the Manual of procedure which accompanied the Lead Grant application.

此申请是第一个参与中心申请 合作弱视分类研究阶段，一项多- 中心、计划、基于协议的项目，以检查现有的 弱视的临床分类及其与A、B、B两种方法的比较 根据弱视眼的表现进行分类 进行了一系列特定的心理和生理测试。浮现的数据 将分析： -确定一组区别于 弱视来自正常的眼睛。 -确定定义不同的视觉行为的集群 弱视的类型。 -确定派生自 心理物理和眼动测量及临床测量 从相同的病人身上收集的。 将使用聚类分析的统计技术来研究 测量临床和心理物理变量以检查 心理物理测量的集群可以是零假设 根据临床分类进行预测，反之亦然。这个 研究对象为弱视受试者和对照受试者 临床症状通常与弱视有关，但 没有弱视和正常受试者。年龄从8岁到8岁不等 35年了。该项目的全部细节载于《手册》 与Lead Grant申请一同提交的程序。