Assessment and Validation of Tongue Fatigue for Speech

言语舌头疲劳的评估和验证

• 批准号: 6665301
• 负责人: NANCY PEARL SOLOMON
• 金额: $ 5.87万
• 依托单位: HENRY M. JACKSON FDN FOR THE ADV MIL/MED
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6665301
• 关键词: Parkinson's disease; amyotrophic lateral sclerosis; behavior test; behavioral /social science research tag; dysarthria; fatigue; human subject; patient oriented research; speech disorders; tongue

DESCRIPTION (provided by applicant): Fatigue is a common clinical symptom in persons with neuromotor disorders, many of whom have a concomitant dysarthria. To track fatigue-related changes with treatment or disease progression, an objective measure is needed to quantify fatigue. The long-term objectives of this research are to validate a clinical assessment of tongue fatigue and to examine the role of tongue fatigue in disordered speech. A noninvasive, nonaversive physiologic assessment technique has been designed and preliminarily tested to reflect the sense of effort associated with fatigue. The first specific aim is to use this technique to test individuals with Parkinson?s disease (PD), amyotrophic lateral sclerosis (ALS), and a group of sex- and age-matched, neurologically normal, control subjects. The benefit of this line of research is to provide a simple objective assessment of fatigue. According to the clinical literature, fatigue can exacerbate dysarthria; however, data are not available to substantiate this claim. The second specific aim of this research, therefore, tests the assumption that speech is more susceptible to fatigue in persons with dysarthria than in normal speakers. The study attempts to induce acute tongue fatigue with speech-like tongue exercises in the same groups of subjects (ALS, PD, neurologically normal) and to demonstrate effects on tongue function. The exercise consists of fast syllable repetitions involving lingual targets and movements. Tongue fatigue, indicated by the fatigue measure tested under Aim 1, is expected after the tongue exercises in the disordered groups. As a control for the potential effects of overall lassitude and reduced motivation, the subjects will perform the task with the hand before and after the speech-like exercises as well; no difference is anticipated. Furthermore, functional effects will be examined by comparing speech produced before and after the tongue exercises. This aim will provide evidence to support the clinical relevance of the exacerbation of dysarthria by fatigue and further validate the constant-effort technique as an indicator of fatigue.

描述（由申请人提供）：疲劳是一种常见的临床症状 患有神经运动障碍的人，其中许多人伴有构音障碍。 为了跟踪治疗或疾病进展过程中与疲劳相关的变化， 需要客观的测量来量化疲劳。的长期目标 这项研究旨在验证舌头疲劳的临床评估并 检查舌头疲劳在言语障碍中的作用。一种非侵入性、 设计并初步设计了非厌恶性生理评估技术 测试以反映与疲劳相关的努力感。第一个 具体目标是使用该技术来测试帕金森氏症患者 疾病（PD），肌萎缩侧索硬化症（ALS），以及一组性别和年龄匹配的， 神经系统正常的对照受试者。这条线的好处 研究的目的是提供一种简单客观的疲劳评估。根据 临床文献显示，疲劳会加剧构音障碍；然而，数据是 无法证实这一说法。本次活动的第二个具体目标 因此，研究检验了言语更容易受到影响的假设 构音障碍患者比正常说话者更容易疲劳。该研究试图 通过类似言语的舌头练习来诱发急性舌头疲劳 受试者组（ALS、PD、神经系统正常）并展示效果 关于舌头功能。该练习包括快速音节重复，涉及 语言目标和动作。舌头疲劳，由疲劳测量表明 在目标 1 下进行测试，预计在无序的舌头练习后 组。作为对整体疲劳和减少的潜在影响的控制 动机，受试者将在执行任务之前和之后用手执行任务 还有类似演讲的练习；预计没有差异。此外， 将通过比较之前和之后产生的语音来检查功能效果 舌头练习后。这一目标将为支持 疲劳和进一步的构音障碍恶化的临床相关性 验证持续努力技术作为疲劳指标的效果。