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Assessment and Validation of Tongue Fatigue for Speech

言语舌头疲劳的评估和验证

基本信息

批准号：
6797432
负责人：
NANCY PEARL SOLOMON
金额：
$ 5.87万
依托单位：
HENRY M. JACKSON FDN FOR THE ADV MIL/MED
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-01 至 2006-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6797432
关键词：
Parkinson&apos s disease amyotrophic lateral sclerosis behavior test behavioral /social science research tag dysarthria fatigue human subject patient oriented research speech disorders tongue

项目摘要

DESCRIPTION (provided by applicant): Fatigue is a common clinical symptom in persons with neuromotor disorders, many of whom have a concomitant dysarthria. To track fatigue-related changes with treatment or disease progression, an objective measure is needed to quantify fatigue. The long-term objectives of this research are to validate a clinical assessment of tongue fatigue and to examine the role of tongue fatigue in disordered speech. A noninvasive, nonaversive physiologic assessment technique has been designed and preliminarily tested to reflect the sense of effort associated with fatigue. The first specific aim is to use this technique to test individuals with Parkinson?s disease (PD), amyotrophic lateral sclerosis (ALS), and a group of sex- and age-matched, neurologically normal, control subjects. The benefit of this line of research is to provide a simple objective assessment of fatigue. According to the clinical literature, fatigue can exacerbate dysarthria; however, data are not available to substantiate this claim. The second specific aim of this research, therefore, tests the assumption that speech is more susceptible to fatigue in persons with dysarthria than in normal speakers. The study attempts to induce acute tongue fatigue with speech-like tongue exercises in the same groups of subjects (ALS, PD, neurologically normal) and to demonstrate effects on tongue function. The exercise consists of fast syllable repetitions involving lingual targets and movements. Tongue fatigue, indicated by the fatigue measure tested under Aim 1, is expected after the tongue exercises in the disordered groups. As a control for the potential effects of overall lassitude and reduced motivation, the subjects will perform the task with the hand before and after the speech-like exercises as well; no difference is anticipated. Furthermore, functional effects will be examined by comparing speech produced before and after the tongue exercises. This aim will provide evidence to support the clinical relevance of the exacerbation of dysarthria by fatigue and further validate the constant-effort technique as an indicator of fatigue.

描述（由申请人提供）：疲劳是一种常见的临床症状，患有神经运动障碍的人，其中许多人伴有构音障碍。为了跟踪治疗或疾病进展中与疲劳相关的变化，需要客观的测量来量化疲劳。的长期目标这项研究旨在验证舌疲劳的临床评估，研究舌疲劳在言语障碍中的作用。一种非侵入性的，设计了一种非厌恶性生理评价技术，测试以反映与疲劳相关的努力感。第一具体目标是使用这种技术来测试个人与帕金森？S 疾病（PD），肌萎缩侧索硬化症（ALS），和一组性别和年龄匹配，神经系统正常的对照组这条线的好处是研究的目的是提供一个简单客观的疲劳评估。根据根据临床文献，疲劳可加重构音障碍;然而，数据无法证实这一说法。第二个具体目标是因此，研究测试了语音更容易受到疲劳与构音障碍的人比在正常的扬声器。本研究试图在相同的环境中用类似于演讲的舌头练习来诱导急性舌头疲劳，受试者组（ALS、PD、神经系统正常），并证明效果舌头的功能。练习包括快速音节重复，语言目标和动作。舌疲劳，由疲劳测量指示根据目标1进行测试，预计在舌头练习后，组作为对整体疲劳的潜在影响的控制，动机，受试者将执行任务的手之前和之后类似演讲的练习也是如此;预计没有区别。此外，委员会认为，功能效果将通过比较之前产生的语音和舌头练习后。这一目标将提供证据支持疲劳引起构音障碍加重的临床相关性，验证恒定努力技术作为疲劳的指标。