Expression profiling of human gliomas by cDNA microarray

虽然人类神经胶质瘤并不代表大多数恶性肿瘤，但它们仍然是一种非常难以治疗的疾病。通过与美国凤凰城Barrow神经学研究所的研究人员合作，我们正在对不同亚型的胶质瘤进行cDNA微阵列实验，以确定用于诊断和预后的基因表达谱，并确定潜在的新治疗靶点。两种特殊的亚型，少突胶质细胞瘤和少星形细胞瘤，很难通过正常病理技术区分，误诊并不罕见。这是一个非常大的问题，因为有治疗少突胶质细胞瘤的方法，误诊通常会导致错误的治疗方案。因此，我们也在试图确定潜在的分子标记，用于特异性区分这两种肿瘤类型。

Although human gliomas do not represent the majority of malignancies, they remain a disease that is very difficult to treat. In collaboration with researchers at the Barrow Neurological Institute, Phoenix, AR, we are performing cDNA microarray experiments on different subtypes of gliomas in order to identify gene expression profiles for diagnosis and prognosis, as well as to identify potential novel therapeutic targets. Two particular subtypes, oligodendoglioma and oligoastrocytoma, are very difficult to distinguish by normal pathological techniques, and misdiagnoses are not uncommon. This is a very big problem as there are treatments for oligodendroglioma, and misdiagnosis usually results in the wrong treatment regiment. Therefore, we are also trying to identify potential molecular markers to be used to specifically differentiate between these two tumor types.