Helicobacter Pylori Infection In Rural Egyptian Children

幽门螺杆菌已被证明可引起慢性活动性胃炎和消化性溃疡疾病，并与胃腺癌的发展有关，胃腺癌是世界上第四大常见癌症。此外，有迹象表明，在发展中国家，儿童时期感染幽门螺杆菌会增加患慢性腹泻、营养不良和生长衰竭的可能性。据估计，全世界每年仅治疗幽门螺杆菌胃炎和消化性溃疡的医疗费用就超过74亿美元。在部分发展中国家，高达90%的人口在10岁之前感染了幽门螺杆菌。确切的传播方式和与幽门螺杆菌感染相关的风险因素在很大程度上是未知的，特别是在发展中国家。在这项研究中，分支调查人员计划描述以人口为基础的埃及农村儿童从出生到三岁的幽门螺杆菌感染的流行病学。该队列的数据库将包括基线社会人口学特征，定期监测饮食和人体测量状况，系统监测以确定病因定义的腹泻疾病，以及系统监测以确定流行和发生的幽门螺杆菌感染。根据这些数据，将计算出幽门螺杆菌感染的年龄特异性发病率。此外，分科调查员将把幽门螺杆菌流行和事件的发生与先前的社会人口学、卫生、行为和饮食特征以及IgA抗h水平联系起来。母乳喂养婴儿摄入的母乳中的幽门螺杆菌抗体。最后，将评估持续性腹泻的发生率以及消瘦和发育不良的风险。迄今为止，279名新生儿已被纳入该研究，其中第一个于1998年2月1日被纳入。没有更多的新生儿，但正在对集合队列进行随访。

Helicobacter pylori has been shown to cause chronic active gastritis and peptic ulcer disease, and it is associated with the development of gastric adenocarcinoma, the fourth most common cancer in the world. Additionally, there is a suggestion that in the developing world, infection with H. pylori in childhood increases the likelihood of developing chronic diarrhea, malnutrition, and growth failure. It is estimated that the yearly world medical cost to treat H. pylori gastritis and peptic ulcer alone exceeds $7.4 billion. In parts of the developing world, up to 90% of the population is infected with H. pylori by ten years of age. The exact mode of transmission and the risk factors associated with the acquisition of an H. pylori infection are largely unknown, especially in the developing world. In this study, Branch investigators plan to describe the epidemiology of H. pylori infection in a population-based cohort of rural Egyptian children followed from birth until three years of age. The database from this cohort will include baseline sociodemographic features, periodic monitoring of diet and anthropometric status, systematic monitoring for ascertainment of etiologically defined diarrheal illnesses, and systematic monitoring for ascertainment of prevalent and incident H. pylori infections. With these data, age-specific incidence rates for H. pylori infection will be calculated. In addition, Branch investigators will relate the occurrence of prevalent and incident H. pylori to antecedent sociodemographic, hygienic, behavioral, and dietary characteristics, and to levels of IgA anti-H. pylori antibodies in breastmilk ingested by breast-feeding infants. Finally, the rates of persistent diarrhea, and the risks of wasting and stunting will be assessed. To date 279 neonates have been enrolled into the study, the first of whom was enrolled on 2/1/98. No further newbirths are being accrued but followup of the assembled cohort is ongoing.