Helicobacter Pylori Infection In Rural Egyptian Children

幽门螺杆菌可引起慢性活动性胃炎和消化性溃疡，并与世界上第四大常见癌症胃腺癌的发生有关。此外，有一种观点认为，在发展中国家，感染H。儿童时期的幽门螺杆菌增加了患慢性腹泻、营养不良和生长障碍的可能性。据估计，世界每年治疗H。仅幽门胃炎和消化性溃疡就超过74亿美元。在部分发展中国家，高达90%的人口感染了H。pylori幽门螺杆菌的发病率确切的传播方式和与获得H.幽门螺杆菌感染在很大程度上是未知的，特别是在发展中国家。在这项研究中，分支研究人员计划描述H.幽门螺杆菌感染的农村埃及儿童人群队列从出生到3岁。该队列的数据库将包括基线社会人口学特征、定期监测饮食和人体测量状态、系统监测以确定病因学定义的腹泻疾病，以及系统监测以确定流行和偶发H。幽门感染根据这些数据，年龄特异性的H。将计算幽门螺杆菌感染。此外，分支调查员将描述流行和事件H的发生情况。pylori与先前的社会人口学、卫生学、行为和饮食特征以及伊加抗H水平有关。母乳喂养婴儿摄入的母乳中的幽门螺杆菌抗体。最后，将评估持续性腹泻的发生率以及消瘦和发育迟缓的风险。迄今为止，已有279名新生儿入组本研究，其中第一例于1998年2月1日入组。没有进一步的新生儿正在积累，但后续的组装队列正在进行中。

Helicobacter pylori has been shown to cause chronic active gastritis and peptic ulcer disease, and it is associated with the development of gastric adenocarcinoma, the fourth most common cancer in the world. Additionally, there is a suggestion that in the developing world, infection with H. pylori in childhood increases the likelihood of developing chronic diarrhea, malnutrition, and growth failure. It is estimated that the yearly world medical cost to treat H. pylori gastritis and peptic ulcer alone exceeds $7.4 billion. In parts of the developing world, up to 90% of the population is infected with H. pylori by ten years of age. The exact mode of transmission and the risk factors associated with the acquisition of an H. pylori infection are largely unknown, especially in the developing world. In this study, Branch investigators plan to describe the epidemiology of H. pylori infection in a population-based cohort of rural Egyptian children followed from birth until three years of age. The database from this cohort will include baseline sociodemographic features, periodic monitoring of diet and anthropometric status, systematic monitoring for ascertainment of etiologically defined diarrheal illnesses, and systematic monitoring for ascertainment of prevalent and incident H. pylori infections. With these data, age-specific incidence rates for H. pylori infection will be calculated. In addition, Branch investigators will relate the occurrence of prevalent and incident H. pylori to antecedent sociodemographic, hygienic, behavioral, and dietary characteristics, and to levels of IgA anti-H. pylori antibodies in breastmilk ingested by breast-feeding infants. Finally, the rates of persistent diarrhea, and the risks of wasting and stunting will be assessed. To date 279 neonates have been enrolled into the study, the first of whom was enrolled on 2/1/98. No further newbirths are being accrued but followup of the assembled cohort is ongoing.